TRIM15 and UBE2N

Number of citations of the paper that reports this interaction (PubMedID 34497368)
64

Data Source:
BioGRID (pull down)

		TRIM15	UBE2N
Description		tripartite motif containing 15	ubiquitin conjugating enzyme E2 N
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Focal Adhesion Anchoring Junction	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Protein-containing Complex Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Molecular Sequestering Activity	Nucleotide Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Canonical NF-kappaB Signal Transduction Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Transport Of Viral Material	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Regulation Of DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination Antiviral Innate Immune Response Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair
Pathways			ISG15 antiviral mechanism NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PINK1-PRKN Mediated Mitophagy CLEC7A (Dectin-1) signaling Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Tonsillitis ( 30037793)	Height ( 18391951) Mean reticulocyte volume ( 32888494)
Interacting Genes		42 interacting genes: ACD ACTB APOA1 AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MAPK3 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2N UBE2U VASP VCL VIM YJU2	124 interacting genes: AMFR ARIH1 ARIH2 ARK2C AURKA BARD1 BCL10 BFAR BIRC2 BIRC3 BIRC8 BRCA1 CADPS2 CBL CCNB1 CHFR CHUK CNOT4 DTL DTX1 DTX3 DZIP3 F12 H2AC4 HERC2 HSP90AA1 LRSAM1 MALT1 MARCHF5 MARCHF7 MDM2 MIB1 MIB2 MID1 MKRN3 MUL1 MYLIP NBN NEDD4L NEURL1 NFX1 OTUB2 PEDS1 PEDS1-UBE2V1 PELI1 PELI3 PJA2 PRKN PTTG1 RBCK1 RBX1 RC3H1 RC3H2 RFFL RFWD3 RIPK1 RNF103 RNF11 RNF111 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF135 RNF152 RNF167 RNF168 RNF181 RNF182 RNF38 RNF4 RNF43 RNF5 RNF8 SH3RF1 SH3RF2 SHPRH SIAH1 SIAH2 SLC2A4 STUB1 TNFAIP3 TOPORS TP53 TRAF2 TRAF6 TREX2 TRIM13 TRIM14 TRIM15 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM27 TRIM28 TRIM31 TRIM32 TRIM33 TRIM34 TRIM39 TRIM5 TRIM50 TRIM54 TRIM63 TRIM65 TRIM69 TRIM7 TRIM72 UBA1 UBB UBE2V1 UBE2V2 UBE3A UBE3B UHRF1 XIAP ZNRF2 ZNRF3 ZNRF4
Entrez ID		89870	7334
HPRD ID		15551	04725
Ensembl ID		ENSG00000204610	ENSG00000177889
Uniprot IDs		Q5SRL0 Q9C019	P61088 V9HW41
PDB IDs		7QS2	1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4IP3 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 4TKP 4WHV 5AIT 5AIU 5EYA 5H7S 5VNZ 5VO0 5YWR 6D6I 6JKY 6KFP 6KG6 6KL4 6LP2 6P5B 6S53 6ULH 6UMP 6UMS 7BBD 7BBF 7BXG 9BIV
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cytoskeleton Regulation Of Cellular Component Organization Anchoring Junction Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Regulation Of Locomotion Cellular Component Assembly Positive Regulation Of Organelle Organization Regulation Of Cell Motility Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Actin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Cell Projection Organization Regulation Of Cell-substrate Junction Organization Positive Regulation Of Intracellular Signal Transduction Actin Cytoskeleton Organization Stress Fiber Regulation Of Cell Migration Cell-cell Adhesion Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Integrin-mediated Signaling Pathway Cell Cortex Actin Filament-based Process Regulation Of Multicellular Organismal Process Cell Adhesion Cell Motility Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Leukocyte Cell-cell Adhesion	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein Polyubiquitination Zinc Ion Binding Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Macromolecule Catabolic Process Metal Ion Binding Protein K63-linked Ubiquitination Protein Autoubiquitination Proteolysis Catabolic Process Protein K48-linked Ubiquitination Response To Stress Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Signaling Regulation Of Cell Communication Protein Monoubiquitination Immune System Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Defense Response To Symbiont Cytoplasm Defense Response To Other Organism Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Response To Other Organism Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Metabolic Process
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