TRIM15 and YJU2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM15	YJU2
Description		tripartite motif containing 15	YJU2 splicing factor homolog
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GO Annotations	Cellular Component	Nucleus Cytoplasm Focal Adhesion Anchoring Junction	Nucleus Nucleoplasm Spliceosomal Complex U2-type Catalytic Step 1 Spliceosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Molecular Sequestering Activity	Protein Binding Metal Ion Binding
	Biological Process	Canonical NF-kappaB Signal Transduction Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Transport Of Viral Material	Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Tonsillitis ( 30037793)
Interacting Genes		42 interacting genes: ACD ACTB APOA1 AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MAPK3 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2N UBE2U VASP VCL VIM YJU2	22 interacting genes: BANP BRAP CCDC57 CEP70 DRC4 EMILIN1 FRS2 GOLGA2 GOLGA6A JADE1 KAT5 LNX2 MAD1L1 MEOX2 REL TFCP2 TRIM15 TRIM21 TRIM27 ZNF143 ZNF526 ZNF829
Entrez ID		89870	55702
HPRD ID		15551	08546
Ensembl ID		ENSG00000204610	ENSG00000105248
Uniprot IDs		Q5SRL0 Q9C019	Q9BW85
PDB IDs		7QS2	5YZG 6ZYM 7A5P 8I0W
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cytoskeleton Regulation Of Cellular Component Organization Anchoring Junction Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Regulation Of Locomotion Cellular Component Assembly Positive Regulation Of Organelle Organization Regulation Of Cell Motility Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Actin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Cell Projection Organization Regulation Of Cell-substrate Junction Organization Positive Regulation Of Intracellular Signal Transduction Actin Cytoskeleton Organization Stress Fiber Regulation Of Cell Migration Cell-cell Adhesion Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Integrin-mediated Signaling Pathway Cell Cortex Actin Filament-based Process Regulation Of Multicellular Organismal Process Cell Adhesion Cell Motility Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Leukocyte Cell-cell Adhesion	Suppression Of Viral Release By Host Regulation Of Type I Interferon Production Canonical NF-kappaB Signal Transduction Zinc Ion Binding Transcription Coactivator Activity Positive Regulation Of Mitotic Sister Chromatid Segregation Histone H4K16 Acetyltransferase Activity Golgi Cis Cisterna Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Organelle Disassembly Regulation Of Metaphase Plate Congression Positive Regulation Of Biosynthetic Process Identical Protein Binding Negative Regulation Of Viral Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Viral Transcription Ubiquitin-protein Transferase Activity Attachment Of Mitotic Spindle Microtubules To Kinetochore Membraneless Organelle Assembly Histone Acetyltransferase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Microtubule Nucleation DNA Binding Regulation Of Viral Process Positive Regulation Of Chromosome Segregation Positive Regulation Of Cell Cycle Spindle Pole Ubiquitin Protein Ligase Activity Mitotic Spindle Pole Attachment Of Spindle Microtubules To Kinetochore Regulation Of Autophagy Innate Immune Response MAD1 Complex Histone H2AK5 Acetyltransferase Activity Regulation Of Protein Binding Positive Regulation Of Autophagy Negative Regulation Of Type I Interferon Production Positive Regulation Of Metabolic Process Cytoskeleton Cis-Golgi Network Organelle Assembly DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Microtubule Cytoskeleton Organization Defense Response To Other Organism Defense Response To Symbiont
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