TRIM15 and EHMT1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		TRIM15	EHMT1
Description		tripartite motif containing 15	euchromatic histone lysine methyltransferase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Focal Adhesion Anchoring Junction	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Body
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Molecular Sequestering Activity	Transcription Corepressor Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3K27 Methyltransferase Activity C2H2 Zinc Finger Domain Binding Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity
	Biological Process	Canonical NF-kappaB Signal Transduction Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Transport Of Viral Material	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Methylation Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Response To Fungicide Positive Regulation Of Cold-induced Thermogenesis Facultative Heterochromatin Formation
Pathways			Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases			Kleefstra syndrome; 9q Subtelomeric deletion syndrome
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Tonsillitis ( 30037793)	Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Metabolite levels ( 23823483)
Interacting Genes		42 interacting genes: ACD ACTB APOA1 AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MAPK3 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2N UBE2U VASP VCL VIM YJU2	13 interacting genes: ATXN1 DNMT3A EED EZH2 H3-4 H3C1 LIG1 LZTR1 PCBD1 SUMO2 TP53 TRIM15 WIZ
Entrez ID		89870	79813
HPRD ID		15551	07383
Ensembl ID		ENSG00000204610	ENSG00000181090
Uniprot IDs		Q5SRL0 Q9C019	A0A1B0GUD1 A0A1B0GV09 Q9H9B1
PDB IDs		7QS2	2IGQ 2RFI 3B7B 3B95 3FPD 3HNA 3MO0 3MO2 3MO5 3SW9 3SWC 4I51 5TTG 5TUZ 5V9J 5VSD 5VSF 6BY9 6MBO 6MBP 7T7M 8XPT
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cytoskeleton Regulation Of Cellular Component Organization Anchoring Junction Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Regulation Of Locomotion Cellular Component Assembly Positive Regulation Of Organelle Organization Regulation Of Cell Motility Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Actin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Cell Projection Organization Regulation Of Cell-substrate Junction Organization Positive Regulation Of Intracellular Signal Transduction Actin Cytoskeleton Organization Stress Fiber Regulation Of Cell Migration Cell-cell Adhesion Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Integrin-mediated Signaling Pathway Cell Cortex Actin Filament-based Process Regulation Of Multicellular Organismal Process Cell Adhesion Cell Motility Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Leukocyte Cell-cell Adhesion	Epigenetic Regulation Of Gene Expression Nucleoplasm Chromatin Remodeling Transcription Corepressor Binding Pronucleus Chromatin Binding Chromatin Organization Cellular Response To Antibiotic Chromatin Silencing Complex Nucleus ESC/E(Z) Complex Regulation Of Gliogenesis Facultative Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Regulatory NcRNA-mediated Heterochromatin Formation Genomic Imprinting Nuclear Matrix Heterochromatin Formation Regulation Of RNA Metabolic Process LncRNA Binding Negative Regulation Of Gene Expression, Epigenetic Epigenetic Programming Of Gene Expression Regulation Of Gene Expression Nucleosome Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding DNA Methylation-dependent Constitutive Heterochromatin Formation Response To Antibiotic Regulation Of Glial Cell Proliferation Negative Regulation Of Transcription By RNA Polymerase II Heterochromatin Hepatocyte Homeostasis Okazaki Fragment Processing Involved In Mitotic DNA Replication Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Protein-cysteine Methyltransferase Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Promoter-specific Chromatin Binding Cellular Response To Trichostatin A Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle DNA Replication, Okazaki Fragment Processing 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity
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