UBE2N and TRIM5

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UBE2N	TRIM5
Gene Name		ubiquitin-conjugating enzyme E2N	tripartite motif containing 5
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol UBC13-MMS2 Complex UBC13-UEV1A Complex Protein Complex Extracellular Vesicular Exosome	Cytoplasmic MRNA Processing Body Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Poly(A) RNA Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Signaling Pattern Recognition Receptor Activity Ligase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA Repair Postreplication Repair Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Histone Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Histone Modification Regulation Of Histone Ubiquitination Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of DNA Repair T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Viral Process Cytokine-mediated Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein Trimerization Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways		Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Class I MHC mediated antigen processing & presentation IRAK1 recruits IKK complex Innate Immune System ISG15 antiviral mechanism TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Interferon Signaling Cytokine Signaling in Immune system MyD88-independent cascade Antiviral mechanism by IFN-stimulated genes Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Adaptive Immune System	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Height ( 18391951)	DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		87 interactors: AMFR ARIH2 AURKA BARD1 BCL10 BFAR BIRC3 BIRC8 BRCA1 CADPS2 CHFR CHUK CNOT4 DTX1 DZIP3 F12 HLTF HSP90AA1 LRSAM1 MALT1 MARCH5 MARCH7 MIB1 MIB2 MID1 MKRN3 MYLIP NBN NEDD4L NEURL1 NFX1 OTUB2 PARK2 PELI1 PELI3 PJA2 RBCK1 RC3H2 RFWD3 RIPK1 RNF103 RNF11 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF152 RNF165 RNF167 RNF182 RNF43 RNF5 RNF8 SH3RF1 SH3RF2 SHPRH SIAH1 SLC2A4 STUB1 TMEM189 TMEM189-UBE2V1 TNFAIP3 TOPORS TP53 TRAF2 TRAF6 TRIM17 TRIM25 TRIM27 TRIM28 TRIM33 TRIM39 TRIM5 TRIM50 TRIM72 UBB UBC UBE2V1 UBE2V2 XIAP ZNRF1 ZNRF2 ZNRF3 ZNRF4	35 interactors: BTBD1 BTBD2 EWSR1 LZTR1 MKRN3 MNAT1 OTUB2 OTUD6A PCBD1 PRKCG PSMC2 SUMO1 TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 USP15 USP2 USP21 USP39 USP5
Entrez ID		7334	85363
HPRD ID		04725	07004
Ensembl ID			ENSG00000132256
Uniprot IDs		P61088	Q9C035
PDB IDs		1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4EPO 4IP3	2ECV 2YRG
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein K63-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Cellular Metabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Ubiquitination Metabolic Process Response To Stress Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Cellular Response To Stress Activation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Proteasomal Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Proteolysis Regulation Of Signaling Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Innate Immune Response Negative Regulation Of Apoptotic Process Regulation Of Innate Immune Response Innate Immune Response Catabolic Process Immune Response Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cell Death	Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein K48-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Proteasomal Protein Catabolic Process Regulation Of Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Innate Immune Response Protein Deubiquitination Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein Modification By Small Protein Removal Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Defense Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Stress Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Protein K48-linked Deubiquitination Regulation Of Type I Interferon Production Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Protein Ubiquitination Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2q1 ube2z ubiquitin ubiquitination	antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trims tripartite ulk1
Tagcloud (Difference) ?		array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2q1 ube2z ubiquitin ubiquitination	antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trims tripartite ulk1
Tagcloud (Intersection) ?