UBE2N and TREX2

Number of citations of the paper that reports this interaction (PubMedID 33357432)
69

Data Source:
BioGRID (pull down)

		UBE2N	TREX2
Description		ubiquitin conjugating enzyme E2 N	three prime repair exonuclease 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Protein-containing Complex Extracellular Exosome	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity	Magnesium Ion Binding Nucleic Acid Binding DNA Binding Nuclease Activity Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding Molecular Adaptor Activity
	Biological Process	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Regulation Of DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination Antiviral Innate Immune Response Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair	DNA Metabolic Process DNA Repair DNA Catabolic Process DNA Damage Response
Pathways		ISG15 antiviral mechanism NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PINK1-PRKN Mediated Mitophagy CLEC7A (Dectin-1) signaling Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Height ( 18391951) Mean reticulocyte volume ( 32888494)
Interacting Genes		124 interacting genes: AMFR ARIH1 ARIH2 ARK2C AURKA BARD1 BCL10 BFAR BIRC2 BIRC3 BIRC8 BRCA1 CADPS2 CBL CCNB1 CHFR CHUK CNOT4 DTL DTX1 DTX3 DZIP3 F12 H2AC4 HERC2 HSP90AA1 LRSAM1 MALT1 MARCHF5 MARCHF7 MDM2 MIB1 MIB2 MID1 MKRN3 MUL1 MYLIP NBN NEDD4L NEURL1 NFX1 OTUB2 PEDS1 PEDS1-UBE2V1 PELI1 PELI3 PJA2 PRKN PTTG1 RBCK1 RBX1 RC3H1 RC3H2 RFFL RFWD3 RIPK1 RNF103 RNF11 RNF111 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF135 RNF152 RNF167 RNF168 RNF181 RNF182 RNF38 RNF4 RNF43 RNF5 RNF8 SH3RF1 SH3RF2 SHPRH SIAH1 SIAH2 SLC2A4 STUB1 TNFAIP3 TOPORS TP53 TRAF2 TRAF6 TREX2 TRIM13 TRIM14 TRIM15 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM27 TRIM28 TRIM31 TRIM32 TRIM33 TRIM34 TRIM39 TRIM5 TRIM50 TRIM54 TRIM63 TRIM65 TRIM69 TRIM7 TRIM72 UBA1 UBB UBE2V1 UBE2V2 UBE3A UBE3B UHRF1 XIAP ZNRF2 ZNRF3 ZNRF4	4 interacting genes: ATF4 MESD POLD1 UBE2N
Entrez ID		7334	11219
HPRD ID		04725	02299
Ensembl ID		ENSG00000177889	ENSG00000183479
Uniprot IDs		P61088 V9HW41	Q9BQ50
PDB IDs		1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4IP3 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 4TKP 4WHV 5AIT 5AIU 5EYA 5H7S 5VNZ 5VO0 5YWR 6D6I 6JKY 6KFP 6KG6 6KL4 6LP2 6P5B 6S53 6ULH 6UMP 6UMS 7BBD 7BBF 7BXG 9BIV	1Y97
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein Polyubiquitination Zinc Ion Binding Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Macromolecule Catabolic Process Metal Ion Binding Protein K63-linked Ubiquitination Protein Autoubiquitination Proteolysis Catabolic Process Protein K48-linked Ubiquitination Response To Stress Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Signaling Regulation Of Cell Communication Protein Monoubiquitination Immune System Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Defense Response To Symbiont Cytoplasm Defense Response To Other Organism Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Response To Other Organism Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Metabolic Process	Postreplication Repair Lewy Body Core Response To Manganese-induced Endoplasmic Reticulum Stress Cellular Response To UV ATF1-ATF4 Transcription Factor Complex L-asparagine Metabolic Process Response To UV Cellular Response To Light Stimulus Cellular Response To Radiation CHOP-ATF4 Complex Positive Regulation Of Sodium-dependent Phosphate Transport DNA Replication Proofreading UBC13-MMS2 Complex ATF4-CREB1 Transcription Factor Complex Asparagine Metabolic Process Delta DNA Polymerase Complex Ubiquitin Conjugating Enzyme Complex GDF15-GFRAL Signaling Pathway Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Sodium-dependent Phosphate Transport Error-free Translesion Synthesis Cellular Response To Nutrient Levels Nucleotide-excision Repair Complex Nucleotide-excision Repair, DNA Gap Filling HRI-mediated Signaling Lens Fiber Cell Morphogenesis Regulation Of Phosphate Transport Response To Light Stimulus Cellular Response To Manganese Ion Positive Regulation Of Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activator Activity Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Mitochondrial Respirasome Assembly CAMP Response Element Binding Protein Binding 3'-5'-DNA Exonuclease Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process PERK-mediated Unfolded Protein Response Leucine Zipper Domain Binding General Transcription Initiation Factor Binding Positive Regulation Of Receptor Clustering Cellular Response To Stress Cellular Response To Leucine Starvation Response To Manganese Ion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Base-excision Repair, Gap-filling Regulation Of Protein K63-linked Ubiquitination Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Nuclear Periphery Response To Radiation
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