UBE2N and BIRC3

Number of citations of the paper that reports this interaction (PMID 16547522)
173

Data Source:
BioGRID (pull down, two hybrid)

		UBE2N	BIRC3
Gene Name		ubiquitin-conjugating enzyme E2N	baculoviral IAP repeat containing 3
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Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol UBC13-MMS2 Complex UBC13-UEV1A Complex Protein Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Membrane Raft
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Poly(A) RNA Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA Repair Postreplication Repair Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Histone Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Histone Modification Regulation Of Histone Ubiquitination Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of DNA Repair T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Spermatogenesis Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Negative Regulation Of Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Innate Immune Response Regulation Of Inflammatory Response Protein Heterooligomerization Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Class I MHC mediated antigen processing & presentation IRAK1 recruits IKK complex Innate Immune System ISG15 antiviral mechanism TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Interferon Signaling Cytokine Signaling in Immune system MyD88-independent cascade Antiviral mechanism by IFN-stimulated genes Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Adaptive Immune System	Activated TLR4 signalling Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System
Drugs
Diseases
GWAS		Height ( 18391951)	MRI atrophy measures ( 21116278) Prostate cancer ( 23535732)
Protein-Protein Interactions		87 interactors: AMFR ARIH2 AURKA BARD1 BCL10 BFAR BIRC3 BIRC8 BRCA1 CADPS2 CHFR CHUK CNOT4 DTX1 DZIP3 F12 HLTF HSP90AA1 LRSAM1 MALT1 MARCH5 MARCH7 MIB1 MIB2 MID1 MKRN3 MYLIP NBN NEDD4L NEURL1 NFX1 OTUB2 PARK2 PELI1 PELI3 PJA2 RBCK1 RC3H2 RFWD3 RIPK1 RNF103 RNF11 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF152 RNF165 RNF167 RNF182 RNF43 RNF5 RNF8 SH3RF1 SH3RF2 SHPRH SIAH1 SLC2A4 STUB1 TMEM189 TMEM189-UBE2V1 TNFAIP3 TOPORS TP53 TRAF2 TRAF6 TRIM17 TRIM25 TRIM27 TRIM28 TRIM33 TRIM39 TRIM5 TRIM50 TRIM72 UBB UBC UBE2V1 UBE2V2 XIAP ZNRF1 ZNRF2 ZNRF3 ZNRF4	37 interactors: BCL10 BIRC5 CASP3 CASP7 CASP9 CD40 CYFIP2 DIABLO DZIP3 GSPT1 HAX1 HTRA2 IKBKE IKBKG MAP3K14 MBTPS1 PACS2 RAF1 RCHY1 RIPK1 RIPK2 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 TRAF3 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19
Entrez ID		7334	330
HPRD ID		04725	03426
Ensembl ID			ENSG00000023445
Uniprot IDs		P61088	Q13489
PDB IDs		1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4EPO 4IP3	2UVL 3EB5 3EB6 3M0A 3M0D
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein K63-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Cellular Metabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Ubiquitination Metabolic Process Response To Stress Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Cellular Response To Stress Activation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Proteasomal Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Proteolysis Regulation Of Signaling Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Innate Immune Response Negative Regulation Of Apoptotic Process Regulation Of Innate Immune Response Innate Immune Response Catabolic Process Immune Response Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cell Death	Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Activation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Immune System Process Apoptotic Process Programmed Cell Death Regulation Of Immune Response Cell Death Death Innate Immune Response Regulation Of Proteolysis Positive Regulation Of Immune System Process Regulation Of Cysteine-type Endopeptidase Activity Defense Response Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Immune Response Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Stress Positive Regulation Of Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Immune System Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2q1 ube2z ubiquitin ubiquitination	binet biology briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Difference) ?		array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2q1 ube2z ubiquitin ubiquitination	binet biology briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Intersection) ?