TRIM15 and FAM151B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TRIM15	FAM151B
Description		tripartite motif containing 15	family with sequence similarity 151 member B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Focal Adhesion Anchoring Junction	Extracellular Space
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Molecular Sequestering Activity	Protein Binding
	Biological Process	Canonical NF-kappaB Signal Transduction Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Transport Of Viral Material	Photoreceptor Cell Development
Pathways
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Tonsillitis ( 30037793)	Proteinuria in chronic kidney disease ( 26420894)
Interacting Genes		42 interacting genes: ACD ACTB APOA1 AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MAPK3 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2N UBE2U VASP VCL VIM YJU2	1 interacting genes: TRIM15
Entrez ID		89870	167555
HPRD ID		15551	18272
Ensembl ID		ENSG00000204610	ENSG00000152380
Uniprot IDs		Q5SRL0 Q9C019	Q6UXP7
PDB IDs		7QS2
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cytoskeleton Regulation Of Cellular Component Organization Anchoring Junction Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Regulation Of Locomotion Cellular Component Assembly Positive Regulation Of Organelle Organization Regulation Of Cell Motility Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Actin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Cell Projection Organization Regulation Of Cell-substrate Junction Organization Positive Regulation Of Intracellular Signal Transduction Actin Cytoskeleton Organization Stress Fiber Regulation Of Cell Migration Cell-cell Adhesion Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Integrin-mediated Signaling Pathway Cell Cortex Actin Filament-based Process Regulation Of Multicellular Organismal Process Cell Adhesion Cell Motility Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Leukocyte Cell-cell Adhesion	Negative Regulation Of Intracellular Transport Of Viral Material Mesodermal Cell Fate Determination Negative Regulation Of Viral Life Cycle Positive Regulation Of RIG-I Signaling Pathway Suppression Of Viral Release By Host Molecular Sequestering Activity Regulation Of RIG-I Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Cell Fate Determination Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Positive Regulation Of Type I Interferon Production Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Viral Life Cycle Regulation Of Type I Interferon Production Regulation Of Viral Process
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