TRIM15 and CFL1

Number of citations of the paper that reports this interaction (PubMedID 25450970)
0

Data Source:
BioGRID (protein complementation assay)

		TRIM15	CFL1
Description		tripartite motif containing 15	cofilin 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Focal Adhesion Anchoring Junction	Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix Lamellipodium Filopodium Axon Growth Cone Cortical Actin Cytoskeleton Cell Leading Edge Lamellipodium Membrane Mitochondrial Membrane Vesicle Ruffle Membrane Cell Projection Neuronal Cell Body Dendritic Spine Extracellular Exosome Cofilin-actin Rod Synaptic Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Molecular Sequestering Activity	Actin Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Actin Filament Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Canonical NF-kappaB Signal Transduction Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Transport Of Viral Material	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Protein Import Into Nucleus Cytoskeleton Organization Actin Filament Organization Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Actin Polymerization Or Depolymerization Response To Virus Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Lamellipodium Assembly Response To Activity Hippocampus Development Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Cell Projection Organization Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Cell Growth Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Synaptic Plasticity Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Embryonic Development Negative Regulation Of Apoptotic Process Response To Amino Acid Host-mediated Activation Of Viral Process Negative Regulation Of Cell Size Positive Regulation Of Proteolysis Cell Motility Modulation Of Chemical Synaptic Transmission Actin Filament Severing Establishment Of Spindle Localization Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Ether Cellular Response To Epidermal Growth Factor Stimulus Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Protein Localization To Cell Leading Edge Negative Regulation Of Postsynaptic Density Organization Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping
Pathways			Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Dodecyldimethylamine N-oxide Copper Artenimol
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Tonsillitis ( 30037793)	Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Neutrophil count ( 32888494) Platelet count ( 32888494) Psoriasis ( 28537254) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		42 interacting genes: ACD ACTB APOA1 AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MAPK3 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2N UBE2U VASP VCL VIM YJU2	46 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CLCN5 ERBB2 ERBB3 ERBB4 ESR1 FLNA FNDC3B HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP MYCBP2 NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SNRPA SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UBE2M UCHL5 WDR1 YWHAG YWHAQ YWHAZ
Entrez ID		89870	1072
HPRD ID		15551	03261
Ensembl ID		ENSG00000204610	ENSG00000172757
Uniprot IDs		Q5SRL0 Q9C019	P23528 V9HWI5
PDB IDs		7QS2	1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W 6UBY 6UC0 6UC4 6VAO
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cytoskeleton Regulation Of Cellular Component Organization Anchoring Junction Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Regulation Of Locomotion Cellular Component Assembly Positive Regulation Of Organelle Organization Regulation Of Cell Motility Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Actin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Cell Projection Organization Regulation Of Cell-substrate Junction Organization Positive Regulation Of Intracellular Signal Transduction Actin Cytoskeleton Organization Stress Fiber Regulation Of Cell Migration Cell-cell Adhesion Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Integrin-mediated Signaling Pathway Cell Cortex Actin Filament-based Process Regulation Of Multicellular Organismal Process Cell Adhesion Cell Motility Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Leukocyte Cell-cell Adhesion	Actin Cytoskeleton Organization Actin Filament-based Process ATP Binding Regulation Of Organelle Organization Regulation Of Cellular Component Organization Nucleotide Binding Focal Adhesion Protein Modification Process Cytoplasm Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Regulation Of Supramolecular Fiber Organization Protein Kinase Activity Regulation Of Multicellular Organismal Process Actin Filament Cytoskeleton Positive Regulation Of Multicellular Organismal Process Mesenchyme Migration Regulation Of Protein Localization To Nucleus Cytoskeleton Organization Regulation Of Membrane Potential Developmental Process Protein Phosphorylation Cell Junction Organization ERBB2 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Actin Filament Organization Kinase Activity Protein-containing Complex Lamellipodium Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Phosphorylation Organelle Organization Positive Regulation Of Cell Activation Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Phosphatase Activity Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Protein Localization To Cell Junction Positive Regulation Of MAPK Cascade Negative Regulation Of Programmed Cell Death Regulation Of Actin Cytoskeleton Organization Protein Serine/threonine Phosphatase Activity
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