TRIM15 and CORO1B

Number of citations of the paper that reports this interaction (PubMedID 25450970)
0

Data Source:
BioGRID (protein complementation assay)

		TRIM15	CORO1B
Description		tripartite motif containing 15	coronin 1B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Focal Adhesion Anchoring Junction	Stress Fiber Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Lamellipodium Cell Leading Edge Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Glutamatergic Synapse
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Molecular Sequestering Activity	Actin Binding Protein Binding Identical Protein Binding Cadherin Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Canonical NF-kappaB Signal Transduction Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Transport Of Viral Material	Actin Filament Organization Cell Migration Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Endothelial Cell Chemotaxis Cellular Response To Platelet-derived Growth Factor Stimulus Wound Healing Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Organization Negative Regulation Of Smooth Muscle Cell Chemotaxis Actin Filament Branching Protein Localization To Cell Leading Edge Positive Regulation Of Lamellipodium Morphogenesis
Pathways
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Tonsillitis ( 30037793)	HDL cholesterol levels ( 32203549) Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278)
Interacting Genes		42 interacting genes: ACD ACTB APOA1 AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MAPK3 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2N UBE2U VASP VCL VIM YJU2	9 interacting genes: ARPC2 FXR1 KPNA2 LHX4 POLR1C PRKCA SSH1 TERF1 TRIM15
Entrez ID		89870	57175
HPRD ID		15551	16743
Ensembl ID		ENSG00000204610	ENSG00000172725
Uniprot IDs		Q5SRL0 Q9C019	Q9BR76
PDB IDs		7QS2
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cytoskeleton Regulation Of Cellular Component Organization Anchoring Junction Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Regulation Of Locomotion Cellular Component Assembly Positive Regulation Of Organelle Organization Regulation Of Cell Motility Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Actin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Cell Projection Organization Regulation Of Cell-substrate Junction Organization Positive Regulation Of Intracellular Signal Transduction Actin Cytoskeleton Organization Stress Fiber Regulation Of Cell Migration Cell-cell Adhesion Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Integrin-mediated Signaling Pathway Cell Cortex Actin Filament-based Process Regulation Of Multicellular Organismal Process Cell Adhesion Cell Motility Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Leukocyte Cell-cell Adhesion	Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of Viral Life Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Viral Penetration Into Host Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cellular Component Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Protein Kinase C Signaling Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Protein-containing Complex Assembly Positive Regulation Of Shelterin Complex Assembly Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Actin Filament Polymerization Muscle Cell Projection Membrane Cell Leading Edge Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Intracellular Transport Of Viral Material Mesodermal Cell Fate Determination Medial Motor Column Neuron Differentiation Nucleus Regulation Of Viral Process Positive Regulation Of Gene Expression Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Angiotensin-activated Signaling Pathway RNA Strand Annealing Activity Nuclear Pore Localization Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization To Telomere Fibrillar Center Shelterin Complex Negative Regulation Of Viral Life Cycle Desmosome Assembly
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