TRIM15 and GTF2E1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TRIM15	GTF2E1
Gene Name		tripartite motif containing 15	general transcription factor IIE, polypeptide 1, alpha 56kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular	Nucleoplasm Intermediate Filament Cytoskeleton
	Molecular Function	Zinc Ion Binding	Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Viral Release From Host Cell	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process
Pathways			RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription HIV Infection RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		14 interactors: ACD EHMT1 FAM151B FAM161A GTF2E1 IRF5 MED7 MYBL2 RABGEF1 SNW1 TAF9B TINF2 TRIM8 UBE2U	28 interactors: AES APP CBFA2T2 CDK7 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E2 GTF2F2 GTF2H1 GTF2H4 IKBKG MDM2 PCBD2 POLR2A SND1 SRPK2 TAF1 TAF11 TAF6 TBP TCEA1 TRIM15 TRIM24 TRIM29 ZBTB9 ZSCAN1
Entrez ID		89870	2960
HPRD ID		15551	01799
Ensembl ID		ENSG00000204610	ENSG00000153767
Uniprot IDs		Q5SRL0 Q9C019	P29083
PDB IDs			1VD4 2JTX 2RNQ 2RNR
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Telomere Assembly Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase DNA-templated Transcription, Initiation Negative Regulation Of Telomere Maintenance Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Telomere Maintenance Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Protein Localization To Chromosome Regulation Of Metabolic Process Regulation Of Chromosome Organization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Negative Regulation Of DNA Replication Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Kit Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Viral Transcription Transcription, DNA-templated Regulation Of RNA Metabolic Process Telomere Maintenance RNA Biosynthetic Process DNA-templated Transcription, Elongation Negative Regulation Of Chromosome Organization Regulation Of Protein ADP-ribosylation Positive Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of DNA Metabolic Process Regulation Of Gene Expression Chromosome Organization DNA Metabolic Process Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Protein Glycosylation Regulation Of DNA Replication Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Component Organization Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Degranulation	Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Transcription Initiation From RNA Polymerase II Promoter Viral Process DNA-templated Transcription, Initiation Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Positive Regulation Of Viral Process Positive Regulation Of Viral Transcription Regulation Of Viral Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Viral Transcription Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process 7-methylguanosine MRNA Capping Positive Regulation Of Cellular Biosynthetic Process 7-methylguanosine RNA Capping Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase I Promoter Nucleotide-excision Repair Positive Regulation Of Metabolic Process Regulation Of Cellular Process Nucleotide-excision Repair, DNA Damage Removal Positive Regulation Of Transcription, DNA-templated MRNA Processing DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?			avenues bioinformatics bl canonical conferring dhx8 disrupted dnaja1 galactosidase hap1 insertional kalrn lytic mechanistic mutagenesis participate queried replication screens share tat throughput tzm uba3 ube2e3 utilizing viable vmp1
Tagcloud (Difference) ?			avenues bioinformatics bl canonical conferring dhx8 disrupted dnaja1 galactosidase hap1 insertional kalrn lytic mechanistic mutagenesis participate queried replication screens share tat throughput tzm uba3 ube2e3 utilizing viable vmp1
Tagcloud (Intersection) ?