TRIM15 and MED7

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TRIM15	MED7
Gene Name		tripartite motif containing 15	mediator complex subunit 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular	Nucleus Nucleoplasm Transcription Factor Complex Mitochondrion Mediator Complex Nuclear Membrane
	Molecular Function	Zinc Ion Binding	RNA Polymerase II Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Viral Release From Host Cell	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ACD EHMT1 FAM151B FAM161A GTF2E1 IRF5 MED7 MYBL2 RABGEF1 SNW1 TAF9B TINF2 TRIM8 UBE2U	22 interactors: CTDP1 ESR1 ESR2 HAUS1 HGS HNF4A IKBKG LZTR1 MED22 MED31 MED8 MED9 PCBD2 PML RBFOX2 RELA RHOXF2 SREBF1 TRIM15 TRIM29 UBE2I ZSCAN1
Entrez ID		89870	9443
HPRD ID		15551	05439
Ensembl ID		ENSG00000204610	ENSG00000155868
Uniprot IDs		Q5SRL0 Q9C019	O43513 Q6IAZ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Telomere Assembly Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase DNA-templated Transcription, Initiation Negative Regulation Of Telomere Maintenance Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Telomere Maintenance Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Protein Localization To Chromosome Regulation Of Metabolic Process Regulation Of Chromosome Organization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Negative Regulation Of DNA Replication Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Kit Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Viral Transcription Transcription, DNA-templated Regulation Of RNA Metabolic Process Telomere Maintenance RNA Biosynthetic Process DNA-templated Transcription, Elongation Negative Regulation Of Chromosome Organization Regulation Of Protein ADP-ribosylation Positive Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of DNA Metabolic Process Regulation Of Gene Expression Chromosome Organization DNA Metabolic Process Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Protein Glycosylation Regulation Of DNA Replication Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Component Organization Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Degranulation	Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Intracellular Estrogen Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of Cellular Process Negative Regulation Of Gene Expression Regulation Of Cell Proliferation Cellular Response To Lipid Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Type I Interferon Production Response To Steroid Hormone Vagina Development Uterus Development Negative Regulation Of Viral Release From Host Cell Steroid Hormone Mediated Signaling Pathway Viral Process Regulation Of Type I Interferon Production Negative Regulation Of Biosynthetic Process Cellular Response To Hormone Stimulus Positive Regulation Of Histone Deacetylation Rhythmic Process Female Genitalia Development Regulation Of Signaling
Tagcloud ?			1h agarose batch bead beads biotinylated centrifugation coactivators comprising concurrently cyclooxygenase detecting enhancer ester evaluating immunoblots incubated pcaf pellet pellets phorbol pulldown room srb7 streptavidin tfii trace transactivators washed
Tagcloud (Difference) ?			1h agarose batch bead beads biotinylated centrifugation coactivators comprising concurrently cyclooxygenase detecting enhancer ester evaluating immunoblots incubated pcaf pellet pellets phorbol pulldown room srb7 streptavidin tfii trace transactivators washed
Tagcloud (Intersection) ?