UBE2N and TRIM72

Number of citations of the paper that reports this interaction (PubMedID 23965929)
57

Data Source:
BioGRID (pull down)

		UBE2N	TRIM72
Description		ubiquitin conjugating enzyme E2 N	tripartite motif containing 72
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Protein-containing Complex Extracellular Exosome	Cytoplasm Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Sarcolemma
	Molecular Function	Nucleotide Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity	Phosphatidylserine Binding Protein Binding Zinc Ion Binding Transferase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Regulation Of DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination Antiviral Innate Immune Response Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair	Plasma Membrane Repair Muscle System Process Exocytosis Muscle Organ Development Negative Regulation Of Myotube Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Protein Homooligomerization
Pathways		ISG15 antiviral mechanism NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PINK1-PRKN Mediated Mitophagy CLEC7A (Dectin-1) signaling Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation	Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS		Height ( 18391951) Mean reticulocyte volume ( 32888494)
Interacting Genes		124 interacting genes: AMFR ARIH1 ARIH2 ARK2C AURKA BARD1 BCL10 BFAR BIRC2 BIRC3 BIRC8 BRCA1 CADPS2 CBL CCNB1 CHFR CHUK CNOT4 DTL DTX1 DTX3 DZIP3 F12 H2AC4 HERC2 HSP90AA1 LRSAM1 MALT1 MARCHF5 MARCHF7 MDM2 MIB1 MIB2 MID1 MKRN3 MUL1 MYLIP NBN NEDD4L NEURL1 NFX1 OTUB2 PEDS1 PEDS1-UBE2V1 PELI1 PELI3 PJA2 PRKN PTTG1 RBCK1 RBX1 RC3H1 RC3H2 RFFL RFWD3 RIPK1 RNF103 RNF11 RNF111 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF135 RNF152 RNF167 RNF168 RNF181 RNF182 RNF38 RNF4 RNF43 RNF5 RNF8 SH3RF1 SH3RF2 SHPRH SIAH1 SIAH2 SLC2A4 STUB1 TNFAIP3 TOPORS TP53 TRAF2 TRAF6 TREX2 TRIM13 TRIM14 TRIM15 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM27 TRIM28 TRIM31 TRIM32 TRIM33 TRIM34 TRIM39 TRIM5 TRIM50 TRIM54 TRIM63 TRIM65 TRIM69 TRIM7 TRIM72 UBA1 UBB UBE2V1 UBE2V2 UBE3A UBE3B UHRF1 XIAP ZNRF2 ZNRF3 ZNRF4	19 interacting genes: ABI2 C1orf216 GSK3B INSR IRS1 MED21 MZT1 NMI RAC1 RIPK1 SMARCD1 TCF12 TRIM32 UBE2D1 UBE2H UBE2I UBE2N VSIG4 ZNF655
Entrez ID		7334	493829
HPRD ID		04725	17412
Ensembl ID		ENSG00000177889	ENSG00000177238
Uniprot IDs		P61088 V9HW41	Q6ZMU5
PDB IDs		1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4IP3 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 4TKP 4WHV 5AIT 5AIU 5EYA 5H7S 5VNZ 5VO0 5YWR 6D6I 6JKY 6KFP 6KG6 6KL4 6LP2 6P5B 6S53 6ULH 6UMP 6UMS 7BBD 7BBF 7BXG 9BIV	3KB5 7XT2 7Y4S
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein Polyubiquitination Zinc Ion Binding Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Macromolecule Catabolic Process Metal Ion Binding Protein K63-linked Ubiquitination Protein Autoubiquitination Proteolysis Catabolic Process Protein K48-linked Ubiquitination Response To Stress Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Signaling Regulation Of Cell Communication Protein Monoubiquitination Immune System Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Defense Response To Symbiont Cytoplasm Defense Response To Other Organism Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Response To Other Organism Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Metabolic Process	Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Polyubiquitination Regulation Of Macromolecule Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Insulin Receptor Complex Positive Regulation Of Post-translational Protein Modification Regulation Of Glycogen Metabolic Process Protein Polyubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Regulation Of Protein Modification Process Positive Regulation Of Signaling Regulation Of Neuron Differentiation Regulation Of Protein Ubiquitination Regulation Of Primary Metabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Immune System Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Catabolic Process Insulin Receptor Signaling Pathway Signaling Adaptor Activity TOR Signaling Regulation Of Metabolic Process Regulation Of Cell Projection Assembly Negative Regulation Of TOR Signaling Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Regulation Of RNA Biosynthetic Process Insulin-like Growth Factor Receptor Binding Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
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