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UBE2N and NEDD4L
Number of citations of the paper that reports this interaction (PubMedID
24071738
)
55
Data Source:
BioGRID
(pull down)
UBE2N
NEDD4L
Description
ubiquitin conjugating enzyme E2 N
NEDD4 like E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Ubiquitin Conjugating Enzyme Complex
UBC13-MMS2 Complex
Protein-containing Complex
Extracellular Exosome
Nucleoplasm
Cytoplasm
Endosome
Multivesicular Body
Golgi Apparatus
Cytosol
Plasma Membrane
Apical Plasma Membrane
Extracellular Exosome
Molecular Function
Nucleotide Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Sodium Channel Regulator Activity
Potassium Channel Inhibitor Activity
Sodium Channel Inhibitor Activity
Transmembrane Transporter Binding
Ubiquitin Protein Ligase Activity
Biological Process
Protein Polyubiquitination
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Repair
Regulation Of DNA Repair
Postreplication Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
DNA Damage Response
Protein Ubiquitination
Cellular Response To Nutrient Levels
TORC1 Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Repair
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein K63-linked Ubiquitination
Antiviral Innate Immune Response
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Double-strand Break Repair
Regulation Of Membrane Depolarization
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Monoatomic Ion Transport
Neuromuscular Junction Development
Protein Ubiquitination
Cell Differentiation
Neuron Projection Development
Receptor Internalization
Regulation Of Protein Stability
Receptor Catabolic Process
Monoatomic Ion Transmembrane Transport
Regulation Of Membrane Potential
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Regulation Of Dendrite Morphogenesis
Regulation Of Synapse Organization
Regulation Of Membrane Repolarization
Regulation Of Biological Quality
Protein K48-linked Ubiquitination
Ventricular Cardiac Muscle Cell Action Potential
Sodium Ion Import Across Plasma Membrane
Negative Regulation Of Potassium Ion Transmembrane Transport
Regulation Of Sodium Ion Transmembrane Transport
Negative Regulation Of Sodium Ion Transmembrane Transport
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Negative Regulation Of Sodium Ion Import Across Plasma Membrane
Positive Regulation Of Dendrite Extension
Negative Regulation Of Protein Localization To Cell Surface
Positive Regulation Of Caveolin-mediated Endocytosis
Pathways
ISG15 antiviral mechanism
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PINK1-PRKN Mediated Mitophagy
CLEC7A (Dectin-1) signaling
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
E3 ubiquitin ligases ubiquitinate target proteins
Interleukin-1 signaling
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
Aggrephagy
Aggrephagy
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Antigen processing: Ubiquitination & Proteasome degradation
Budding and maturation of HIV virion
Downregulation of TGF-beta receptor signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Stimuli-sensing channels
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Alanine aminotransferase levels (
34315874
33547301
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Aspartate aminotransferase levels (
34315874
33547301
)
Childhood body mass index (
33045005
)
Diastolic blood pressure (
30224653
)
Diisocyanate-induced asthma (
25918132
)
Gamma glutamyl transferase levels (
33339817
29403010
)
Insomnia (caffeine-induced) (
22754043
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
33972514
)
Manganese levels (
26025379
)
Response to amphetamines (
22952603
)
Serum alkaline phosphatase levels (
33339817
33547301
)
Interacting Genes
124 interacting genes:
AMFR
ARIH1
ARIH2
ARK2C
AURKA
BARD1
BCL10
BFAR
BIRC2
BIRC3
BIRC8
BRCA1
CADPS2
CBL
CCNB1
CHFR
CHUK
CNOT4
DTL
DTX1
DTX3
DZIP3
F12
H2AC4
HERC2
HSP90AA1
LRSAM1
MALT1
MARCHF5
MARCHF7
MDM2
MIB1
MIB2
MID1
MKRN3
MUL1
MYLIP
NBN
NEDD4L
NEURL1
NFX1
OTUB2
PEDS1
PEDS1-UBE2V1
PELI1
PELI3
PJA2
PRKN
PTTG1
RBCK1
RBX1
RC3H1
RC3H2
RFFL
RFWD3
RIPK1
RNF103
RNF11
RNF111
RNF115
RNF122
RNF125
RNF126
RNF128
RNF13
RNF130
RNF135
RNF152
RNF167
RNF168
RNF181
RNF182
RNF38
RNF4
RNF43
RNF5
RNF8
SH3RF1
SH3RF2
SHPRH
SIAH1
SIAH2
SLC2A4
STUB1
TNFAIP3
TOPORS
TP53
TRAF2
TRAF6
TREX2
TRIM13
TRIM14
TRIM15
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM27
TRIM28
TRIM31
TRIM32
TRIM33
TRIM34
TRIM39
TRIM5
TRIM50
TRIM54
TRIM63
TRIM65
TRIM69
TRIM7
TRIM72
UBA1
UBB
UBE2V1
UBE2V2
UBE3A
UBE3B
UHRF1
XIAP
ZNRF2
ZNRF3
ZNRF4
151 interacting genes:
AATF
ABL1
ABL2
ACVR1B
ACY3
ADAP2
AICDA
AKT1
AKT3
AMOT
APEX2
ARHGDIA
ARRB1
ARRB2
AURKC
BBX
BMPR1A
CACNB1
CAMK1D
CDC34
CDK3
CDK5
CEP55
CHLSN
CLIC2
CUEDC1
CYBRD1
CYP26B1
DAPK3
DAZAP2
DDX54
DECR2
DMTN
DYRK3
EFEMP2
FGF12
FKBP3
FOXO1
GORAB
GRIA1
H1-0
HAX1
HNRNPD
HSPA5
IFRD2
IKBKB
IL6ST
KCNAB1
KCNAB2
KCNAB3
KCNB1
KIF3B
KIFC3
LAPTM5
MAGEB1
MAP1LC3A
MAP2
MAP3K20
MAP3K3
MAP3K5
MAPKAPK3
MARK2
MERTK
MINK1
MOB3A
MRPL19
NDFIP2
NEAT1
NEIL3
NHP2
NR3C1
NSRP1
NTRK1
NUDT16L1
OGG1
PBX1
PDCD6IP
PIP4P2
PRKX
PRR16
PRRG1
PRRG2
PSMD4
PTGR3
PYM1
RANBP10
RASL10B
RASL11B
RHOB
RNF11
RNF7
ROBO3
RPL30
RPS6KB2
SCAMP3
SCD
SCN5A
SCNN1A
SCNN1B
SCNN1G
SENP2
SERPINF1
SGK1
SGK2
SIVA1
SLC7A7
SLC9A3
SMAD2
SMAD3
SMAD7
SNCA
SP1
SPAG8
SRMS
STAC
STK40
TAF1B
TARBP2
TBC1D7
TCEAL2
TGFB1I1
TMA16
TRAF3
TRIM41
UBAC1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2N
ULK1
USP7
VDAC2
WBP2
WNK4
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
YY1
ZC3HAV1L
ZDHHC3
Entrez ID
7334
23327
HPRD ID
04725
05903
Ensembl ID
ENSG00000177889
ENSG00000049759
Uniprot IDs
P61088
V9HW41
A0A1B0GVY1
B7Z2P9
B7Z6K0
Q96PU5
PDB IDs
1J7D
2C2V
3HCT
3HCU
3VON
3W31
4DHI
4DHJ
4DHZ
4IP3
4NR3
4NRG
4NRI
4ONL
4ONM
4ONN
4ORH
4TKP
4WHV
5AIT
5AIU
5EYA
5H7S
5VNZ
5VO0
5YWR
6D6I
6JKY
6KFP
6KG6
6KL4
6LP2
6P5B
6S53
6ULH
6UMP
6UMS
7BBD
7BBF
7BXG
9BIV
2LAJ
2LB2
2LTY
2MPT
2NSQ
2ONI
3JVZ
3JW0
5HPK
6ZBT
6ZC9
7LP1
7LP2
7LP3
7LP4
7LP5
7NMZ
Enriched GO Terms of Interacting Partners
?
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Transferase Activity
Protein Polyubiquitination
Zinc Ion Binding
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Macromolecule Catabolic Process
Metal Ion Binding
Protein K63-linked Ubiquitination
Protein Autoubiquitination
Proteolysis
Catabolic Process
Protein K48-linked Ubiquitination
Response To Stress
Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
Regulation Of Signal Transduction
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Post-translational Protein Modification
Positive Regulation Of Protein Metabolic Process
Cellular Response To Stress
Regulation Of Intracellular Signal Transduction
Innate Immune Response
Regulation Of Signaling
Regulation Of Cell Communication
Protein Monoubiquitination
Immune System Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Defense Response To Symbiont
Cytoplasm
Defense Response To Other Organism
Positive Regulation Of Macromolecule Metabolic Process
Ubiquitin Protein Ligase Binding
Response To Other Organism
Ubiquitin Conjugating Enzyme Binding
Positive Regulation Of Metabolic Process
Ubiquitin Conjugating Enzyme Activity
Protein Kinase Activity
ATP Binding
Protein Serine/threonine Kinase Activity
Protein Modification Process
Ubiquitin Protein Ligase Binding
Kinase Activity
Nucleotide Binding
Protein Serine Kinase Activity
Protein Phosphorylation
Transferase Activity
Phosphorylation
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Cell Communication
Protein Polyubiquitination
Protein Metabolic Process
Regulation Of Signaling
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cytosol
Macromolecule Metabolic Process
Modification-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Proteolysis Involved In Protein Catabolic Process
Response To Nutrient Levels
Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Cytoplasm
Regulation Of Transport
Protein Autophosphorylation
Cellular Response To Oxygen-containing Compound
Protein Domain Specific Binding
Regulation Of TORC1 Signaling
Regulation Of Protein Ubiquitination
Transmembrane Transporter Binding
Protein K11-linked Ubiquitination
Signal Transduction
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
TORC1 Signaling
Protein Sequestering Activity
Macromolecule Catabolic Process
Nucleus
Regulation Of TOR Signaling
Negative Regulation Of TORC1 Signaling
Potassium Channel Regulator Activity
Regulation Of Intracellular Signal Transduction
MAPK Cascade
Negative Regulation Of Signal Transduction
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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