TRIM15 and FERMT2

Number of citations of the paper that reports this interaction (PubMedID 25450970)
0

Data Source:
BioGRID (protein complementation assay)

		TRIM15	FERMT2
Description		tripartite motif containing 15	FERM domain containing kindlin 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Focal Adhesion Anchoring Junction	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Cell Junction Lamellipodium Membrane I Band Cell Projection Anchoring Junction
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Molecular Sequestering Activity	Actin Binding Integrin Binding Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Protein Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding Protein Serine/threonine Kinase Activator Activity SMAD Binding Actin Filament Binding Protein Serine/threonine Kinase Binding
	Biological Process	Canonical NF-kappaB Signal Transduction Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Transport Of Viral Material	Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Integrin Activation Positive Regulation Of Integrin Activation Adherens Junction Maintenance Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Vascular Permeability Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Focal Adhesion Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Limb Development Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Protein Localization To Cell Junction Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Pathways			Cell-extracellular matrix interactions RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Tonsillitis ( 30037793)	Alzheimer's disease (late onset) ( 24162737) Diastolic blood pressure ( 27841878) Glaucoma (primary angle closure) ( 27064256) Intraocular pressure ( 29617998 29785010 30054594 31959993) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 30046033 32439900) Prostate cancer ( 23535732) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28135244)
Interacting Genes		42 interacting genes: ACD ACTB APOA1 AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MAPK3 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2N UBE2U VASP VCL VIM YJU2	9 interacting genes: APP CMTM5 CTNNB1 FBLIM1 ILK ITGB1 LIMS1 PARVA TRIM15
Entrez ID		89870	10979
HPRD ID		15551	06374
Ensembl ID		ENSG00000204610	ENSG00000073712
Uniprot IDs		Q5SRL0 Q9C019	Q96AC1
PDB IDs		7QS2	2LGX 2LKO 2MSU 4F7H 6U4N 6XTJ
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cytoskeleton Regulation Of Cellular Component Organization Anchoring Junction Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Regulation Of Locomotion Cellular Component Assembly Positive Regulation Of Organelle Organization Regulation Of Cell Motility Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Actin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Cell Projection Organization Regulation Of Cell-substrate Junction Organization Positive Regulation Of Intracellular Signal Transduction Actin Cytoskeleton Organization Stress Fiber Regulation Of Cell Migration Cell-cell Adhesion Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Integrin-mediated Signaling Pathway Cell Cortex Actin Filament-based Process Regulation Of Multicellular Organismal Process Cell Adhesion Cell Motility Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Leukocyte Cell-cell Adhesion	Anchoring Junction Focal Adhesion Cell Adhesion Cell-cell Adhesion Cell-substrate Adhesion Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Neural Precursor Cell Proliferation Regulation Of Neural Precursor Cell Proliferation Cell-matrix Adhesion Developmental Cell Growth Regulation Of Developmental Process Positive Regulation Of Signal Transduction Developmental Growth Involved In Morphogenesis Regulation Of Neurotransmitter Uptake Integrin Binding Protein Kinase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Neuroblast Proliferation Lamellipodium Cell Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Heterotypic Cell-cell Adhesion Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Canonical Wnt Signaling Pathway Intercalated Disc Regulation Of Neuroblast Proliferation Neuroblast Proliferation Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Junction Assembly Perinuclear Region Of Cytoplasm Cellular Response To Growth Factor Stimulus Positive Regulation Of Neural Precursor Cell Proliferation Amyloid-beta Complex Regulation Of Wnt Signaling Pathway Growth Cone Lamellipodium Synaptic Membrane Regulation Of Synapse Organization Visual Behavior Regulation Of Response To Calcium Ion Response To Growth Factor Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Visual Learning
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