TRIM15 and FBLIM1

Number of citations of the paper that reports this interaction (PubMedID 25450970)
0

Data Source:
BioGRID (protein complementation assay)

		TRIM15	FBLIM1
Description		tripartite motif containing 15	filamin binding LIM protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Focal Adhesion Anchoring Junction	Fibrillar Center Stress Fiber Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Junction Anchoring Junction Cell Periphery
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Molecular Sequestering Activity	Protein Binding Filamin Binding Metal Ion Binding
	Biological Process	Canonical NF-kappaB Signal Transduction Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Transport Of Viral Material	Cell Adhesion Regulation Of Cell Shape Regulation Of Integrin Activation Cell-cell Adhesion
Pathways			Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Tonsillitis ( 30037793)	Alcoholic chronic pancreatitis ( 28754779) Cardiac Troponin-T levels ( 23247143) Gut microbiota (bacterial taxa) ( 27723756) Heel bone mineral density ( 30598549)
Interacting Genes		42 interacting genes: ACD ACTB APOA1 AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MAPK3 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2N UBE2U VASP VCL VIM YJU2	10 interacting genes: ACTMAP ADAT3 FERMT2 FLNA FLNB H3-5 H3C1 LMO3 SHISA6 TRIM15
Entrez ID		89870	54751
HPRD ID		15551	09669
Ensembl ID		ENSG00000204610	ENSG00000162458
Uniprot IDs		Q5SRL0 Q9C019	Q8WUP2
PDB IDs		7QS2	2K9U 2W0P 4P3W
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cytoskeleton Regulation Of Cellular Component Organization Anchoring Junction Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Regulation Of Locomotion Cellular Component Assembly Positive Regulation Of Organelle Organization Regulation Of Cell Motility Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Actin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Cell Projection Organization Regulation Of Cell-substrate Junction Organization Positive Regulation Of Intracellular Signal Transduction Actin Cytoskeleton Organization Stress Fiber Regulation Of Cell Migration Cell-cell Adhesion Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Integrin-mediated Signaling Pathway Cell Cortex Actin Filament-based Process Regulation Of Multicellular Organismal Process Cell Adhesion Cell Motility Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Leukocyte Cell-cell Adhesion	Anchoring Junction Focal Adhesion Cell Cortex Actin Filament Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading SMAD Binding Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Filament Bundle Assembly Cadherin Binding Protein Localization To Cell Junction Fc-gamma Receptor I Complex Binding Actin Binding Positive Regulation Of Protein Localization To Nucleus Tubulin Deacetylation Myb Complex Stress Fiber Structural Constituent Of Chromatin Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Mesodermal Cell Fate Determination Initiator Methionyl Aminopeptidase Activity Cysteine-type Aminopeptidase Activity Formation Of Radial Glial Scaffolds Establishment Of Sertoli Cell Barrier Nucleosome Asymmetric, Glutamatergic, Excitatory Synapse Regulation Of AMPA Glutamate Receptor Clustering
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