HERC2 and XPA

Number of citations of the paper that reports this interaction (PMID 23178497)
4

Data Source:
BioGRID (enzymatic study)

		HERC2	XPA
Gene Name		HECT and RLD domain containing E3 ubiquitin protein ligase 2	xeroderma pigmentosum, complementation group A
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Inner Membrane Centriole Membrane	Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Golgi Apparatus Intercellular Bridge
	Molecular Function	Ubiquitin-protein Transferase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Ligase Activity Heme Binding Ubiquitin Protein Ligase Binding SUMO Binding	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	DNA Repair Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Spermatogenesis Protein Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of GTPase Activity	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Multicellular Organism Growth
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS		Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Eye color ( 23548203 23118974) Eye color traits ( 20463881) Hair color ( 23548203) Iris color ( 18252221) Tanning ( 23548203) Vitiligo ( 22561518)	Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		7 interactors: BRCA1 CALM1 CDC42 RNF11 TP53 UBE2D3 XPA	20 interactors: ATM ATR DDB1 DDB2 ERCC1 ERCC6 GPN1 GTF2E2 GTF2H1 HERC2 MSH2 MSH3 NDEL1 PRKDC RASSF1 RPA1 RPA2 RPA4 TRIM27 XAB2
Entrez ID		8924	7507
HPRD ID		06905	02045
Ensembl ID		ENSG00000128731	ENSG00000136936
Uniprot IDs		A8KAQ8 O95714	P23025
PDB IDs		2KEO 3KCI 4L1M	1D4U 1XPA 2JNW
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cellular Amino Acid Metabolic Process Multicellular Organism Growth Response To Abiotic Stimulus Response To Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Regulation Of Cell Cycle Process DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Cellular Ketone Metabolic Process DNA Repair Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Process Cellular Response To DNA Damage Stimulus Substantia Nigra Development Intracellular Signal Transduction Positive Regulation Of Cell Cycle Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Modification Process Protein Autoubiquitination Regulation Of Cell Cycle Apoptotic Process Response To Light Stimulus Programmed Cell Death Apoptotic Signaling Pathway Neural Nucleus Development Cell Death DNA Metabolic Process Death Regulation Of Cytokinesis Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Histone Modification Blood Coagulation Positive Regulation Of Cell Cycle Arrest Hemostasis Positive Regulation Of Neuron Death Regulation Of Intracellular Transport Positive Regulation Of Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Immune Response-regulating Signaling Pathway Immune Response Midbrain Development Growth Negative Regulation Of Gene Expression Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Signal Transduction In Response To DNA Damage Cellular Response To Light Stimulus	DNA Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair, DNA Damage Removal DNA Recombination Transcription-coupled Nucleotide-excision Repair Response To Stress Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Response To UV Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Response To Radiation DNA Catabolic Process DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Cell Cycle Process Response To Abiotic Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cell Cycle Checkpoint Cell Cycle Chromosome Organization Aromatic Compound Catabolic Process Pyrimidine Dimer Repair Response To Gamma Radiation Mismatch Repair Cellular Response To Stimulus Immunoglobulin Production Cellular Macromolecule Catabolic Process Response To Light Stimulus Cellular Response To Heat Telomere Maintenance Mitotic Cell Cycle Process Reproduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Organelle Organization Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Response To X-ray Mitotic Recombination
Tagcloud ?		attributed bleomycin chemotherapeutic coordinates cph cul7 depletion disrupted e3 ectopic hect inactivation interacts interference involves kinds ligase linking maintained mdm2 oligomerization p53 parc posttranslational proteasome reduces relevance stressed tetramerization
Tagcloud (Difference) ?		attributed bleomycin chemotherapeutic coordinates cph cul7 depletion disrupted e3 ectopic hect inactivation interacts interference involves kinds ligase linking maintained mdm2 oligomerization p53 parc posttranslational proteasome reduces relevance stressed tetramerization
Tagcloud (Intersection) ?