HERC2

Description		HECT and RLD domain containing E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centriole Cytosol Cytoskeleton Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding SUMO Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Repair Intracellular Protein Transport DNA Damage Response Spermatogenesis Protein Ubiquitination Neuron Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adiponectin levels ( 33562295) Age-related macular degeneration ( 32741009) Asthma and eczema ( 34155719) Basal cell carcinoma ( 31174203) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Bone mineral content ( 31790847) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Colorectal cancer ( 29228715) Corneal astigmatism ( 30306274) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Diisocyanate-induced asthma ( 25918132) Eye color ( 23548203 30664655 23118974) Eye color (brightness) ( 30664655) Eye color (hue) ( 30664655) Eye color (saturation) ( 30664655) Eye color traits ( 20463881 30166351) Hair color ( 26926045 29662168 23548203 30664655) Hair morphology traits ( 30166351) Intraocular pressure ( 31959993) Iris color ( 18252221) Iris color (b* coordinate) ( 30895295) Iris color (L* coordinate) ( 30895295) Iris heterochromicity ( 30895295) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Monobrow ( 27182965) Nevus count or cutaneous melanoma ( 32341527) Perceived skin darkness ( 25963972) Red vs. brown/black hair color ( 30531825) Refractive astigmatism ( 30306274) Rosacea symptom severity ( 29771307) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655 31315583) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 25963972) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Tanning ( 23548203) Type 2 diabetes ( 32499647) Uveal melanoma ( 28781888) Vitiligo ( 22561518 27723757)
Interacting Genes		15 interacting genes: BDKRB2 C5AR2 CALM1 CDC42 ERG PDE9A RNF11 STK11 TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2L3 UBE2N XPA
Entrez ID		8924
HPRD ID		06905
Ensembl ID		ENSG00000128731
Uniprot IDs		A8KAQ8 O95714
PDB IDs		2KEO 3KCI 4L1M 6WW3 6WW4 7Q40 7Q41 7Q42 7Q43 7Q44 7Q45 7Q46 7RGW
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Modification Process Protein K48-linked Ubiquitination Post-translational Protein Modification Catabolic Process Macromolecule Catabolic Process Negative Regulation Of TORC1 Signaling Ubiquitin-protein Transferase Activator Activity Proteolysis Protein Autoubiquitination Nucleoplasm Golgi Localization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Cytosol Positive Regulation Of Post-translational Protein Modification Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of TOR Signaling Regulation Of Protein Polyubiquitination Nucleotide Binding Transferase Activity Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Positive Regulation Of Protein Targeting To Mitochondrion Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Regulation Of Protein Ubiquitination Substantia Nigra Development Regulation Of Protein Targeting To Mitochondrion ATP Binding Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Nucleotide-excision Repair, DNA Damage Recognition
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