HERC2 and UBE2D3

Number of citations of the paper that reports this interaction (PMID 20631078)
14

Data Source:
BioGRID (pull down)

		HERC2	UBE2D3
Gene Name		HECT and RLD domain containing E3 ubiquitin protein ligase 2	ubiquitin-conjugating enzyme E2D 3
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Inner Membrane Centriole Membrane	Nucleoplasm Cytosol Plasma Membrane Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Ligase Activity Heme Binding Ubiquitin Protein Ligase Binding SUMO Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	DNA Repair Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Spermatogenesis Protein Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of GTPase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Polyubiquitination Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway DNA Repair Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Protein Ubiquitination BMP Signaling Pathway Negative Regulation Of Type I Interferon Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Hypoxia
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Loss of Function of TGFBR2 in Cancer Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Negative regulators of RIG-I/MDA5 signaling Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Activated TLR4 signalling Generic Transcription Pathway Class I MHC mediated antigen processing & presentation Innate Immune System TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer MyD88-independent cascade Loss of Function of TGFBR1 in Cancer RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Eye color ( 23548203 23118974) Eye color traits ( 20463881) Hair color ( 23548203) Iris color ( 18252221) Tanning ( 23548203) Vitiligo ( 22561518)
Protein-Protein Interactions		7 interactors: BRCA1 CALM1 CDC42 RNF11 TP53 UBE2D3 XPA	180 interactors: AMBRA1 AMFR ARIH1 ARIH2 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 BTRC CADPS2 CBL CBLC CHFR CNOT4 CREB3L1 CREB3L2 CUL3 DBN1 DDX58 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL2 FBXO2 FBXO25 FBXO32 FBXW11 FBXW8 FOCAD FZR1 HDAC6 HERC1 HERC2 HUWE1 IKBKG ITCH KAT2B KIAA1107 LRSAM1 MAP3K1 MARCH3 MARCH5 MARCH7 MARCH8 MDM2 MDM4 MEX3B MGRN1 MIB1 MID1 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYLIP NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 OTUB1 PARK2 PCNA PDCD5 PJA1 PJA2 POLL POLM PRPF19 RABGEF1 RBCK1 RBX1 RELA RFFL RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF168 RNF181 RNF185 RNF2 RNF220 RNF25 RNF26 RNF31 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RPLP1 RSPRY1 SAT1 SH3RF1 SHARPIN SIAH1 SIAH2 SKP1 SMURF1 SMURF2 STAM2 STAU1 STK25 STUB1 SYVN1 TOPORS TRAF6 TRAIP TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM63 TRIM68 TRIM7 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBC UBE3A UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF2 WSB1 WWP2 XIAP XPNPEP1 ZNRF1 ZNRF2 ZNRF4
Entrez ID		8924	7323
HPRD ID		06905	04269
Ensembl ID		ENSG00000128731	ENSG00000109332
Uniprot IDs		A8KAQ8 O95714	D6RAH7 P61077
PDB IDs		2KEO 3KCI 4L1M	1X23 2FUH 3L1Z 3RPG 3UGB
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cellular Amino Acid Metabolic Process Multicellular Organism Growth Response To Abiotic Stimulus Response To Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Regulation Of Cell Cycle Process DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Cellular Ketone Metabolic Process DNA Repair Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Process Cellular Response To DNA Damage Stimulus Substantia Nigra Development Intracellular Signal Transduction Positive Regulation Of Cell Cycle Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Modification Process Protein Autoubiquitination Regulation Of Cell Cycle Apoptotic Process Response To Light Stimulus Programmed Cell Death Apoptotic Signaling Pathway Neural Nucleus Development Cell Death DNA Metabolic Process Death Regulation Of Cytokinesis Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Histone Modification Blood Coagulation Positive Regulation Of Cell Cycle Arrest Hemostasis Positive Regulation Of Neuron Death Regulation Of Intracellular Transport Positive Regulation Of Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Immune Response-regulating Signaling Pathway Immune Response Midbrain Development Growth Negative Regulation Of Gene Expression Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Signal Transduction In Response To DNA Damage Cellular Response To Light Stimulus	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Cellular Metabolic Process Proteolysis Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Protein Monoubiquitination Metabolic Process Protein K48-linked Ubiquitination Regulation Of Signal Transduction Regulation Of Protein Ubiquitination Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stress Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Metabolic Process Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Positive Regulation Of Protein Ubiquitination Response To Stress Negative Regulation Of Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Negative Regulation Of Signaling Response To Stimulus Histone Ubiquitination Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Intracellular Signal Transduction
Tagcloud ?		attributed bleomycin chemotherapeutic coordinates cph cul7 depletion disrupted e3 ectopic hect inactivation interacts interference involves kinds ligase linking maintained mdm2 oligomerization p53 parc posttranslational proteasome reduces relevance stressed tetramerization	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube3a ubea5 ubiquinase
Tagcloud (Difference) ?		attributed bleomycin chemotherapeutic coordinates cph cul7 depletion disrupted e3 ectopic hect inactivation interacts interference involves kinds ligase linking maintained mdm2 oligomerization p53 parc posttranslational proteasome reduces relevance stressed tetramerization	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube3a ubea5 ubiquinase
Tagcloud (Intersection) ?