HERC3 and TRIM14

Number of citations of the paper that reports this interaction (PubMedID 29053956)
0

Data Source:
BioGRID (two hybrid)

		HERC3	TRIM14
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 3	tripartite motif containing 14
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoplasmic Vesicle	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Adaptor Activity Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination	Immune System Process Inflammatory Response Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K48-linked Deubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		A body shape index ( 34021172) Hair greying ( 26926045) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Multiple sclerosis ( 31604244)
Interacting Genes		17 interacting genes: BTRC CCL22 CD33 EIF5A2 HERC6 MAPK1 NME2 RPL23A SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2	85 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 DHX58 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652
Entrez ID		8916	9830
HPRD ID		16093	05948
Ensembl ID		ENSG00000138641	ENSG00000106785
Uniprot IDs		B4DK41 H0Y8G9 Q15034	Q14142
PDB IDs			6JBM
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Proteolysis Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cytosol Protein Modification By Small Protein Conjugation Pyrimidine-containing Compound Metabolic Process Cytoplasm Protein Tag Activity Mammary Gland Epithelial Cell Proliferation Autophagosome Assembly Autophagosome Organization Positive Regulation Of ERAD Pathway Positive Regulation Of Protein Ubiquitination Nucleus Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of ERAD Pathway Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Metabolic Process Vacuole Organization Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Pyrimidine-containing Compound Biosynthetic Process Transferase Activity Regulation Of Protein Ubiquitination Mitochondrial Outer Membrane Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Proteasomal Protein Catabolic Process Cytosolic Large Ribosomal Subunit ATP Binding ITP Biosynthetic Process Protein Histidine Kinase Activity Cytosine Metabolic Process Cellular Response To Nutrient Levels Thymidine Kinase Activity Negative Regulation Of TORC1 Signaling
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