HERC3 and CD33

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HERC3	CD33
Gene Name		HECT and RLD domain containing E3 ubiquitin protein ligase 3	CD33 molecule
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasmic Membrane-bounded Vesicle	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity	Receptor Activity Protein Binding Carbohydrate Binding
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Proliferation
Pathways
Drugs			Gemtuzumab ozogamicin
Diseases
GWAS			Alzheimer's disease ( 18976728) Alzheimer's disease (late onset) ( 21460841)
Protein-Protein Interactions		11 interactors: CCL22 CD33 HERC6 NME2 TK1 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2	6 interactors: HERC3 KRT31 KRT40 PTPN11 PTPN6 SRC
Entrez ID		8916	945
HPRD ID		16093	01165
Ensembl ID		ENSG00000138641	ENSG00000105383
Uniprot IDs		B4DK41 F5GWU0 Q15034	P20138 Q546G0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Protein Ubiquitination Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Protein Ubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Toll-like Receptor 3 Signaling Pathway Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Viral Protein Processing Negative Regulation Of Protein Ubiquitination Toll-like Receptor Signaling Pathway Cellular Macromolecule Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process Mitotic Cell Cycle Checkpoint Notch Receptor Processing Transcription Initiation From RNA Polymerase II Promoter Virion Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transferase Activity	Abortive Mitotic Cell Cycle T Cell Costimulation Megakaryocyte Development Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Platelet Formation Positive Regulation Of Homotypic Cell-cell Adhesion Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Megakaryocyte Differentiation Regulation Of Response To Interferon-gamma Leukocyte Migration Bone Development Positive Regulation Of Cell-cell Adhesion Myeloid Cell Differentiation Regulation Of MAP Kinase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Lymphocyte Activation Blood Coagulation Hemostasis Regulation Of Intracellular Transport Response To Peptide Hormone Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Cellular Response To Insulin Stimulus Skeletal System Development Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Wound Healing Ephrin Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Adhesion Hemopoiesis Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion
Tagcloud ?		amyotrophic annotation ataxia bac clathrin cloning encode giant glu gly gly483glu gtpases hect herc1 lifespan ligases pigmentosa positional purkinje pyruvate rcc1 recessive retardation retinitis sterility tambaleante underline unexpected	abnormalities allowing antigens author capacities carefully cd11b defective discrepancies english fi fluorochromes granules granulocytes granulopoiesis inconsistencies mature maturing medline monocytes perspectives pools preparing publications retrieved reviewing sensors standardization storage
Tagcloud (Difference) ?		amyotrophic annotation ataxia bac clathrin cloning encode giant glu gly gly483glu gtpases hect herc1 lifespan ligases pigmentosa positional purkinje pyruvate rcc1 recessive retardation retinitis sterility tambaleante underline unexpected	abnormalities allowing antigens author capacities carefully cd11b defective discrepancies english fi fluorochromes granules granulocytes granulopoiesis inconsistencies mature maturing medline monocytes perspectives pools preparing publications retrieved reviewing sensors standardization storage
Tagcloud (Intersection) ?