HERC3

Name	HECT and RLD domain containing E3 ubiquitin protein ligase 3
Structure	No pdb structure
Interactors	17 interactors: BTRC CCL22 CD33 EIF5A2 HERC6 MAPK1 NME2 RPL23A SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2
GO Annotations	Cellular Component	Cytoplasm Cytoplasmic Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways	Antigen processing: Ubiquitination & Proteasome degradation
GWAS	A body shape index ( 34021172 ) Hair greying ( 26926045 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Entrez ID	8916
HPRD ID	16093
Ensembl ID	ENSG00000138641
Uniprot IDs	B4DK41 H0Y8G9 Q15034
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Modification-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Proteolysis Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cytosol Protein Modification By Small Protein Conjugation Pyrimidine-containing Compound Metabolic Process Cytoplasm Protein Tag Activity Mammary Gland Epithelial Cell Proliferation Autophagosome Assembly Autophagosome Organization Positive Regulation Of ERAD Pathway Positive Regulation Of Protein Ubiquitination Nucleus Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of ERAD Pathway Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Metabolic Process Vacuole Organization Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Pyrimidine-containing Compound Biosynthetic Process Transferase Activity Regulation Of Protein Ubiquitination Mitochondrial Outer Membrane Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Proteasomal Protein Catabolic Process Cytosolic Large Ribosomal Subunit ATP Binding ITP Biosynthetic Process Protein Histidine Kinase Activity Cytosine Metabolic Process Cellular Response To Nutrient Levels Thymidine Kinase Activity Negative Regulation Of TORC1 Signaling