TRIM14 and STK38

Number of citations of the paper that reports this interaction (PubMedID 29053956)
0

Data Source:
BioGRID (two hybrid)

		TRIM14	STK38
Description		tripartite motif containing 14	serine/threonine kinase 38
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle	Nucleus Chromosome Cytoplasm Cytosol Site Of Double-strand Break Glutamatergic Synapse
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Adaptor Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Cadherin Binding Metal Ion Binding Protein Serine Kinase Activity Ubiquitin-like Protein Reader Activity Histone Reader Activity UFM1-modified Protein Reader Activity
	Biological Process	Immune System Process Inflammatory Response Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K48-linked Deubiquitination	DNA Damage Checkpoint Signaling Chromatin Organization Protein Phosphorylation DNA Damage Response Negative Regulation Of Metabolic Process Intracellular Signal Transduction Protein Modification Process Negative Regulation Of MAP Kinase Activity Postsynapse Organization
Pathways		Interferon gamma signaling	RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Multiple sclerosis ( 31604244)	Mean platelet volume ( 32888494) Subclinical trait of interstitial lung disease (basilar percentage of high attenuation areas on CT scan) ( 28521775) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		85 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 DHX58 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652	16 interacting genes: BANP CALM1 CTDP1 H2AC20 H2BC21 H3C6 HERC5 HRAS MOB2 S100B SENP2 TRAF3 TRIM14 TRIM25 YWHAB YWHAZ
Entrez ID		9830	11329
HPRD ID		05948	09511
Ensembl ID		ENSG00000106785	ENSG00000112079
Uniprot IDs		Q14142	Q15208
PDB IDs		6JBM	1PSB 6BXI
Enriched GO Terms of Interacting Partners?			Defense Response To Other Organism Innate Immune Response Phosphoserine Residue Binding Response To Other Organism Defense Response To Symbiont Nucleus Immune Response Structural Constituent Of Chromatin Response To External Biotic Stimulus Defense Response Nucleoplasm Cadherin Binding Nucleosome Ubiquitin Protein Ligase Activity Perinuclear Region Of Cytoplasm Protein Sequestering Activity Regulation Of Synaptic Plasticity Immune System Process Negative Regulation Of Protein Localization To Nucleus Long-term Synaptic Potentiation Cytoplasm Regulation Of Neuronal Synaptic Plasticity MRNA Transcription Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity GTPase Complex Regulation Of Defense Response To Virus Ubiquitin-protein Transferase Activity Synaptic Target Recognition TFIIF-class Transcription Factor Complex Binding PKR/eIFalpha Signaling Defense Response To Virus Calcium-dependent Protein Binding Cytosol Antiviral Innate Immune Response Protein Modification Process
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