TRIM14 and ATP1B3

Number of citations of the paper that reports this interaction (PubMedID 29053956)
0

Data Source:
BioGRID (two hybrid)

		TRIM14	ATP1B3
Description		tripartite motif containing 14	ATPase Na+/K+ transporting subunit beta 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle	Cytoplasm Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Basolateral Plasma Membrane Apical Plasma Membrane Sperm Flagellum Melanosome Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Adaptor Activity Ubiquitin Protein Ligase Activity	ATPase Activator Activity Protein Binding Protein-macromolecule Adaptor Activity ATPase Binding Transporter Activator Activity
	Biological Process	Immune System Process Inflammatory Response Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K48-linked Deubiquitination	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Intracellular Potassium Ion Homeostasis Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Stabilization Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Repolarization Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		Interferon gamma signaling	Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Bisacodyl Tegoprazan
Diseases
GWAS		Multiple sclerosis ( 31604244)	Blond vs. brown/black hair color ( 30531825) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulse pressure ( 27841878) Red cell distribution width ( 27863252 28957414 32888494) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 26503584) Total hippocampal volume ( 30279459) Waist-hip ratio ( 28552196) White blood cell count ( 32888494)
Interacting Genes		85 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 DHX58 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652	14 interacting genes: BAALC BARD1 BRCA1 CTXN3 NLRP3 OGT PAXIP1 PEA15 SMAGP STOM TMEM98 TRIM14 UPF2 USP4
Entrez ID		9830	483
HPRD ID		05948	03521
Ensembl ID		ENSG00000106785	ENSG00000069849
Uniprot IDs		Q14142	P54709
PDB IDs		6JBM
Enriched GO Terms of Interacting Partners?			Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification DNA Strand Resection Involved In Replication Fork Processing RNA Polymerase Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Damage Checkpoint Protein K6-linked Ubiquitination Ubiquitin Protein Ligase Activity Response To Ionizing Radiation Negative Regulation Of Gene Expression Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Homologous Recombination Post-translational Protein Modification Negative Regulation Of Macromolecule Metabolic Process Pyroptotic Inflammatory Response Regulation Of Protein Localization Negative Regulation Of MRNA 3'-end Processing Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Adenosine Receptor Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Mitotic G2/M Transition Checkpoint Negative Regulation Of Metabolic Process DNA Recombination Regulation Of Protein Metabolic Process TORC1 Signaling Negative Regulation Of Protein Metabolic Process Positive Regulation Of TORC1 Signaling Circadian Regulation Of Gene Expression Protein Modification Process Protein Polyubiquitination Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Regulation Of Protein Modification Process Negative Regulation Of Protein Ubiquitination Regulation Of Macromolecule Biosynthetic Process
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