TRIM14 and CCDC6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM14	CCDC6
Description		tripartite motif containing 14	coiled-coil domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle	Cytoplasm Cytosol Cytoskeleton
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Adaptor Activity Ubiquitin Protein Ligase Activity	Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding Identical Protein Binding
	Biological Process	Immune System Process Inflammatory Response Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K48-linked Deubiquitination	Cytoskeleton Organization
Pathways		Interferon gamma signaling
Drugs
Diseases			Thyroid cancer
GWAS		Multiple sclerosis ( 31604244)	Alopecia areata ( 25608926) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		85 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 DHX58 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652	31 interacting genes: ATF2 ATF5 CCDC136 CCDC33 CREB1 CSNK2A1 CYTH4 DRC4 DSCR9 FBXW7 LHX3 LRSAM1 LUZP4 MAPK3 MAPK7 MEOX2 PAX6 PIN1 PPP4C SH3RF1 SNAPC1 SORBS3 TFIP11 TRIM14 UBE2I WAC ZNF250 ZNF354C ZNF620 ZNF774 ZNF835
Entrez ID		9830	8030
HPRD ID		05948	09064
Ensembl ID		ENSG00000106785	ENSG00000108091
Uniprot IDs		Q14142	Q05CP8 Q16204
PDB IDs		6JBM
Enriched GO Terms of Interacting Partners?			Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Nucleus Phosphothreonine Residue Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Pituitary Gland Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Catabolic Process MAPK Cascade Transcription Coregulator Binding Protein Stabilization Positive Regulation Of Xenophagy Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Gland Development Negative Regulation Of Proteolysis Signal Transduction In Response To DNA Damage DNA Binding CAMP Response Element Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Autophagy MAP Kinase Activity Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Damage Response Positive Regulation Of Catabolic Process Positive Regulation Of Macromolecule Metabolic Process
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