TRIM14 and PTPN21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM14	PTPN21
Description		tripartite motif containing 14	protein tyrosine phosphatase non-receptor type 21
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle	Cytoplasm Cytoskeleton
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Adaptor Activity Ubiquitin Protein Ligase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Immune System Process Inflammatory Response Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K48-linked Deubiquitination	Protein Dephosphorylation
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)	Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		85 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 DHX58 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652	27 interacting genes: AKAP1 ATOSB BAG3 BMX CATSPER1 CWC22 ERBB4 FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 UBASH3B VPS26C YAP1 ZNF497
Entrez ID		9830	11099
HPRD ID		05948	04468
Ensembl ID		ENSG00000106785	ENSG00000070778
Uniprot IDs		Q14142	Q16825
PDB IDs		6JBM	8GVL 8GVV 8GWH 8GXE 8Y8Y
Enriched GO Terms of Interacting Partners?			Protein Phosphorylation Cardiac Muscle Tissue Regeneration Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Phosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Centriolar Satellite Tissue Regeneration Intestinal Epithelial Cell Development Protein Kinase Activity U2-type Catalytic Step 1 Spliceosome Microtubule-based Process Columnar/cuboidal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Cytoskeleton Kinase Activity Establishment Of Planar Polarity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein ERBB2 Signaling Pathway Mitotic Spindle Organization Spindle Assembly Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Polarized Epithelial Cell Differentiation Positive Regulation Of Protein Localization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cardiac Muscle Cell Proliferation
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