HERC3 and HERC6

Number of citations of the paper that reports this interaction (PMID 18535780)
6

Data Source:
HPRD (in vivo)

		HERC3	HERC6
Gene Name		HECT and RLD domain containing E3 ubiquitin protein ligase 3	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasmic Membrane-bounded Vesicle	Nucleus Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity	Ubiquitin-protein Transferase Activity Ligase Activity
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Hematopoietic Progenitor Cell Differentiation Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS			Metabolite levels ( 22916037)
Protein-Protein Interactions		11 interactors: CCL22 CD33 HERC6 NME2 TK1 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2	3 interactors: HERC3 HERC4 NME2
Entrez ID		8916	55008
HPRD ID		16093	13647
Ensembl ID		ENSG00000138641	ENSG00000138642
Uniprot IDs		B4DK41 F5GWU0 Q15034	Q8IVU3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Protein Ubiquitination Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Protein Ubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Toll-like Receptor 3 Signaling Pathway Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Viral Protein Processing Negative Regulation Of Protein Ubiquitination Toll-like Receptor Signaling Pathway Cellular Macromolecule Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process Mitotic Cell Cycle Checkpoint Notch Receptor Processing Transcription Initiation From RNA Polymerase II Promoter Virion Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transferase Activity	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Peptidyl-histidine Phosphorylation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Nucleobase-containing Small Molecule Interconversion Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Keratinocyte Differentiation Cellular Protein Modification Process Positive Regulation Of Epidermal Cell Differentiation Regulation Of Keratinocyte Differentiation GTP Biosynthetic Process UTP Biosynthetic Process Cellular Macromolecule Catabolic Process GTP Metabolic Process UTP Metabolic Process Positive Regulation Of Epidermis Development CTP Biosynthetic Process Nucleoside Diphosphate Phosphorylation Response To Testosterone Pyrimidine Ribonucleotide Biosynthetic Process Regulation Of Epidermal Cell Differentiation Cellular Response To Fatty Acid Pyrimidine Nucleoside Biosynthetic Process Response To Amine Cellular Protein Metabolic Process Negative Regulation Of Myeloid Leukocyte Differentiation Pyrimidine Nucleotide Biosynthetic Process Cellular Response To Drug Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Cellular Response To Glucose Stimulus Regulation Of Epidermis Development Pyrimidine Nucleoside Metabolic Process Response To Fatty Acid Hippocampus Development Positive Regulation Of Epithelial Cell Differentiation Pyrimidine Nucleotide Metabolic Process Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Nucleoside Triphosphate Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation Proteolysis Limbic System Development Protein Metabolic Process Regulation Of Myeloid Leukocyte Differentiation Response To CAMP
Tagcloud ?		amyotrophic annotation ataxia bac clathrin cloning encode giant glu gly gly483glu gtpases hect herc1 lifespan ligases pigmentosa positional purkinje pyruvate rcc1 recessive retardation retinitis sterility tambaleante underline unexpected	al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Difference) ?		amyotrophic annotation ataxia bac clathrin cloning encode giant glu gly gly483glu gtpases hect herc1 lifespan ligases pigmentosa positional purkinje pyruvate rcc1 recessive retardation retinitis sterility tambaleante underline unexpected	al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Intersection) ?