HERC3 and CCL22

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HERC3	CCL22
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 3	C-C motif chemokine ligand 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoplasmic Vesicle	Extracellular Region Extracellular Space
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Cytokine Activity Protein Binding Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Chemokine receptors bind chemokines Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS		A body shape index ( 34021172) Hair greying ( 26926045) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Asthma ( 32296059) Blood protein levels ( 30072576) Multiple sclerosis ( 24076602) Systemic lupus erythematosus ( 28714469 33272962)
Interacting Genes		17 interacting genes: BTRC CCL22 CD33 EIF5A2 HERC6 MAPK1 NME2 RPL23A SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2	10 interacting genes: AQP6 CCL14 CCL19 CCR4 CRYAB DPP4 GCLC HERC3 PF4V1 VCAM1
Entrez ID		8916	6367
HPRD ID		16093	04263
Ensembl ID		ENSG00000138641	ENSG00000102962
Uniprot IDs		B4DK41 H0Y8G9 Q15034	O00626
PDB IDs
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Proteolysis Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cytosol Protein Modification By Small Protein Conjugation Pyrimidine-containing Compound Metabolic Process Cytoplasm Protein Tag Activity Mammary Gland Epithelial Cell Proliferation Autophagosome Assembly Autophagosome Organization Positive Regulation Of ERAD Pathway Positive Regulation Of Protein Ubiquitination Nucleus Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of ERAD Pathway Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Metabolic Process Vacuole Organization Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Pyrimidine-containing Compound Biosynthetic Process Transferase Activity Regulation Of Protein Ubiquitination Mitochondrial Outer Membrane Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Proteasomal Protein Catabolic Process Cytosolic Large Ribosomal Subunit ATP Binding ITP Biosynthetic Process Protein Histidine Kinase Activity Cytosine Metabolic Process Cellular Response To Nutrient Levels Thymidine Kinase Activity Negative Regulation Of TORC1 Signaling	Chemotaxis Locomotion Cell Chemotaxis Chemokine Activity Cell Migration Inflammatory Response Chemokine-mediated Signaling Pathway Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response Response To Stress Antimicrobial Humoral Response CCR Chemokine Receptor Binding Regulation Of Neutrophil Chemotaxis Cytokine Activity Regulation Of Neutrophil Migration T Cell Costimulation Nitrate Transmembrane Transporter Activity Immune System Process Cell Surface Positive Regulation Of T Cell Activation Regulation Of Granulocyte Chemotaxis Glucagon Processing Regulation Of Cell Activation Humoral Immune Response Positive Regulation Of Dendritic Cell Dendrite Assembly Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion Response To Hypoxia PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Extracellular Region Response To Lipid Response To Oxygen Levels Response To Decreased Oxygen Levels Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Cellular Response To Thyroxine Stimulus Negative Regulation Of Hepatic Stellate Cell Activation Glutamate-cysteine Ligase Activity Glutamate-cysteine Ligase Complex Granulocyte Chemotaxis CCR7 Chemokine Receptor Binding CCL19-activated CCR7 Signaling Pathway Peripheral Nervous System Neuron Differentiation Response To Heat Granulocyte Migration Cell Adhesion Molecule Binding Regulation Of Leukocyte Cell-cell Adhesion
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