HERC3 and CCL22

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HERC3	CCL22
Gene Name		HECT and RLD domain containing E3 ubiquitin protein ligase 3	chemokine (C-C motif) ligand 22
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasmic Membrane-bounded Vesicle	Extracellular Region Extracellular Space
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity	Chemokine Activity
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Cell Chemotaxis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CCL22 CD33 HERC6 NME2 TK1 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2	7 interactors: CCL19 CCR4 CRYAB DPP4 GCLC HERC3 VCAM1
Entrez ID		8916	6367
HPRD ID		16093	04263
Ensembl ID		ENSG00000138641	ENSG00000102962
Uniprot IDs		B4DK41 F5GWU0 Q15034	O00626
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Protein Ubiquitination Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Protein Ubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Toll-like Receptor 3 Signaling Pathway Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Viral Protein Processing Negative Regulation Of Protein Ubiquitination Toll-like Receptor Signaling Pathway Cellular Macromolecule Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process Mitotic Cell Cycle Checkpoint Notch Receptor Processing Transcription Initiation From RNA Polymerase II Promoter Virion Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transferase Activity	Response To Abiotic Stimulus Positive Regulation Of T Cell Activation Cellular Homeostasis Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Proliferation Cell Migration Response To Lipid Response To Stress Response To Hypoxia Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cell Motility Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Lymphocyte Activation Response To Oxidative Stress Inflammatory Response T Cell Costimulation Response To Radiation Response To Organic Substance Locomotion Response To Inorganic Substance Regulation Of Cell Activation Positive Regulation Of T Cell Proliferation Leukocyte Activation Positive Regulation Of Dendritic Cell Dendrite Assembly Homeostatic Process Single Organismal Cell-cell Adhesion Cellular Chemical Homeostasis Positive Regulation Of Chemotaxis Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Stress-activated MAPK Cascade Positive Regulation Of Lymphocyte Proliferation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Mononuclear Cell Proliferation Chemotaxis Regulation Of Cell Adhesion Positive Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Activation Response To Ionizing Radiation Regulation Of T Cell Proliferation Immune System Development Myeloid Dendritic Cell Chemotaxis Regulation Of Dendritic Cell Dendrite Assembly
Tagcloud ?		amyotrophic annotation ataxia bac clathrin cloning encode giant glu gly gly483glu gtpases hect herc1 lifespan ligases pigmentosa positional purkinje pyruvate rcc1 recessive retardation retinitis sterility tambaleante underline unexpected	27cm3 39cm3 alternatively capacities cd163 considering correlate cultivation documented emt hazard hcc hepatocellular infiltration injuries invasiveness m2 macrophage macrophages mesenchymal mhcc97l nodules orthotopic proven quantified scavenger snail tumour venous
Tagcloud (Difference) ?		amyotrophic annotation ataxia bac clathrin cloning encode giant glu gly gly483glu gtpases hect herc1 lifespan ligases pigmentosa positional purkinje pyruvate rcc1 recessive retardation retinitis sterility tambaleante underline unexpected	27cm3 39cm3 alternatively capacities cd163 considering correlate cultivation documented emt hazard hcc hepatocellular infiltration injuries invasiveness m2 macrophage macrophages mesenchymal mhcc97l nodules orthotopic proven quantified scavenger snail tumour venous
Tagcloud (Intersection) ?