TRIM14 and WRNIP1

Number of citations of the paper that reports this interaction (PubMedID 29053956)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TRIM14	WRNIP1
Description		tripartite motif containing 14	WRN helicase interacting protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle	Chromosome, Telomeric Region Nucleus Cytoplasm Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Adaptor Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding DNA Binding Protein Binding ATP Binding Enzyme Activator Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Immune System Process Inflammatory Response Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K48-linked Deubiquitination	DNA Synthesis Involved In DNA Repair Immune System Process DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response Regulation Of DNA-templated DNA Replication Initiation Innate Immune Response
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)	Plateletcrit ( 32888494)
Interacting Genes		85 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 DHX58 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652	14 interacting genes: ABL1 CEBPA ERBB3 FXR1 PIK3R3 PIN1 POLD1 POLD2 POLD4 RNF26 TOLLIP TRIM14 UBC WRN
Entrez ID		9830	56897
HPRD ID		05948	10494
Ensembl ID		ENSG00000106785	ENSG00000124535
Uniprot IDs		Q14142	Q96S55
PDB IDs		6JBM	3VHS 3VHT
Enriched GO Terms of Interacting Partners?			Delta DNA Polymerase Complex DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Response To Stress DNA-templated DNA Replication DNA Replication Macromolecule Metabolic Process Bubble DNA Binding Cellular Response To Stress Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Intracellular Signaling Cassette DNA Repair 3'-5' Exonuclease Activity Positive Regulation Of Macromolecule Metabolic Process Four-way Junction DNA Binding DNA Conformation Change Ubiquitin Protein Ligase Binding DNA-directed DNA Polymerase Activity Translesion Synthesis Positive Regulation Of Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Mismatch Repair DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Postreplication Repair Positive Regulation Of Gene Expression DNA Damage Response Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Long-term Synaptic Potentiation Phosphotyrosine Residue Binding Protein Localization To Cytoplasmic Microtubule Plus-end Positive Regulation Of Developmental Process Nucleobase-containing Compound Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cis-trans Isomerase Activity Exonuclease Activity Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Inflammatory Response Canonical NF-kappaB Signal Transduction Positive Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process
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