HERC3 and EIF5A2

Number of citations of the paper that reports this interaction (PubMedID 35064108)
32

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)

		HERC3	EIF5A2
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 3	eukaryotic translation initiation factor 5A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoplasmic Vesicle	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	RNA Binding Translation Elongation Factor Activity Protein Binding Ribosome Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination	Translation Translational Elongation Spermatogenesis Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Hypusine synthesis from eIF5A-lysine
Drugs
Diseases
GWAS		A body shape index ( 34021172) Hair greying ( 26926045) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	C-reactive protein levels ( 30388399) Urate levels ( 31578528)
Interacting Genes		17 interacting genes: BTRC CCL22 CD33 EIF5A2 HERC6 MAPK1 NME2 RPL23A SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2	10 interacting genes: CDC23 DHPS FNDC3B HERC3 HIF1A NIF3L1 PTBP2 RAB30 REL SDCBP
Entrez ID		8916	56648
HPRD ID		16093	10426
Ensembl ID		ENSG00000138641	ENSG00000163577
Uniprot IDs		B4DK41 H0Y8G9 Q15034	Q9GZV4
PDB IDs
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Proteolysis Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cytosol Protein Modification By Small Protein Conjugation Pyrimidine-containing Compound Metabolic Process Cytoplasm Protein Tag Activity Mammary Gland Epithelial Cell Proliferation Autophagosome Assembly Autophagosome Organization Positive Regulation Of ERAD Pathway Positive Regulation Of Protein Ubiquitination Nucleus Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of ERAD Pathway Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Metabolic Process Vacuole Organization Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Pyrimidine-containing Compound Biosynthetic Process Transferase Activity Regulation Of Protein Ubiquitination Mitochondrial Outer Membrane Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Proteasomal Protein Catabolic Process Cytosolic Large Ribosomal Subunit ATP Binding ITP Biosynthetic Process Protein Histidine Kinase Activity Cytosine Metabolic Process Cellular Response To Nutrient Levels Thymidine Kinase Activity Negative Regulation Of TORC1 Signaling
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