TRIM14 and CENPC

Number of citations of the paper that reports this interaction (PubMedID 29053956)
0

Data Source:
BioGRID (two hybrid)

		TRIM14	CENPC
Description		tripartite motif containing 14	centromere protein C
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Inner Kinetochore Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Cytosol Nuclear Body Midbody
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Adaptor Activity Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding Centromeric DNA Binding Identical Protein Binding
	Biological Process	Immune System Process Inflammatory Response Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K48-linked Deubiquitination	Mitotic Cell Cycle Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Spindle Attachment To Meiosis I Kinetochore
Pathways		Interferon gamma signaling	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Walking pace ( 33128006)
Interacting Genes		85 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 DHX58 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652	8 interacting genes: CIP2A DAXX ELOC MAPK14 MDC1 SUMO2 TRIM14 UBTF
Entrez ID		9830	1060
HPRD ID		05948	00315
Ensembl ID		ENSG00000106785	ENSG00000145241
Uniprot IDs		Q14142	Q03188
PDB IDs		6JBM	5LSJ 5LSK 6MUO 6MUP 6SE6 6SEE 6SEF 7PII 7QOO 7R5R 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Post-translational Protein Modification Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Damage Checkpoint Signaling Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide DNA-templated Transcription Initiation RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Broken Chromosome Clustering PML Body Regulation Of RNA Metabolic Process Regulation Of Synaptic Membrane Adhesion Regulation Of Macromolecule Metabolic Process Target-directed MiRNA Degradation Elongin Complex Regulation Of Glucose Mediated Signaling Pathway Signal Transduction In Response To DNA Damage Cellular Response To Sodium Arsenite RNA Polymerase I General Transcription Initiation Factor Activity Nucleoplasm NFAT Protein Binding Response To Sodium Arsenite Cellular Response To Salt Mitogen-activated Protein Kinase P38 Binding Regulation Of Metabolic Process Stress-induced Premature Senescence Protein-DNA Complex Assembly Chromosome Protein Modification By Small Protein Conjugation Cellular Response To Stress NLRP1 Inflammasome Complex Assembly Transcription Initiation At RNA Polymerase I Promoter Protein Modification Process RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition RNA Polymerase I Preinitiation Complex Assembly
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