MCM3AP and CDC73

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MCM3AP	CDC73
Gene Name		minichromosome maintenance complex component 3 associated protein	cell division cycle 73
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Nucleus Nucleoplasm Cdc73/Paf1 Complex
	Molecular Function	DNA Binding Transferase Activity, Transferring Acyl Groups	RNA Polymerase II Core Binding Protein Binding
	Biological Process	Immune System Process DNA Replication Protein Import Into Nucleus MRNA Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Proliferation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666240)	Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		19 interactors: APC CDC25A CDC42 CDC73 CLSTN1 CRMP1 ENY2 EP300 FAM118B MCM3 NUDT5 POLR2G RAC1 SMAD3 SMAD9 SUV39H2 TAF1D TMEM216 TSC22D1	30 interactors: ALAS1 ANXA6 CCDC155 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 HAP1 HIST1H1C HSF2BP HSPA4 ITFG1 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 PITHD1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TSGA10 VPS37B WWC1
Entrez ID		8888	79577
HPRD ID		04483	09581
Ensembl ID		ENSG00000160294	ENSG00000134371
Uniprot IDs		O60318	Q6P1J9
PDB IDs		4DHX
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Stability Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Cell-cell Junction Organization Posttranscriptional Regulation Of Gene Expression RNA Biosynthetic Process Anatomical Structure Morphogenesis Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Cell Cycle DNA-templated Transcription, Elongation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Pseudopodium Assembly Regulation Of Cell Cycle Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of MRNA 3'-end Processing Response To Hypoxia Positive Regulation Of Cell Death Chromosome Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of MRNA 3'-end Processing Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Projection Assembly Epithelium Development Response To Abiotic Stimulus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Positive Regulation Of Cell Adhesion Tissue Development Biosynthetic Process Histone Modification Stem Cell Maintenance Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Wnt Signaling Pathway Cell Development	Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Histone H2B Ubiquitination Cellular Localization Positive Regulation Of Glycoprotein Biosynthetic Process Establishment Of Localization In Cell Genitalia Morphogenesis Positive Regulation Of Glycoprotein Metabolic Process Organelle Organization Histone Monoubiquitination Regulation Of Glycoprotein Biosynthetic Process Establishment Of Protein Localization To Organelle Protein Localization Chromosome Organization Histone Ubiquitination Protein Import Positive Regulation Of Epithelial To Mesenchymal Transition Cellular Process Cytoplasmic Transport Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Methylation Intracellular Transport Positive Regulation Of Neurogenesis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Organ Growth Organelle Localization Transcription-coupled Nucleotide-excision Repair Regulation Of Oligodendrocyte Differentiation Protein Targeting Protein Monoubiquitination Myoblast Differentiation Regulation Of Intracellular Transport Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Potassium Ion Export Regulation Of Myelination Positive Regulation Of Intracellular Signal Transduction Skin Morphogenesis Vesicle Localization Regulation Of Histone Methylation Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Development Genitalia Development Regulation Of Intracellular Signal Transduction Skin Development Regulation Of Epithelial To Mesenchymal Transition Protein Localization To Organelle Protein Transmembrane Transport
Tagcloud ?		adenomatous arhgap causative cntn6 cnv cnvs ctnnb1 etiologically filtered focad german germline hsph1 kiaa1797 kif26b mining mutyh ngs nonrecurrent polyposis predispose predisposition prioritized silico stringent truncating uncover unexplained ybey	1379delt affecting caucasian encoded fibroma hpt hyperparathyroidism hystologically instrumental jaw jt l460lfs mandible modelling moiety mtt ossifying parafibromin parathyroid partners proband pth relatives sanger sca silico terminus underlie vast
Tagcloud (Difference) ?		adenomatous arhgap causative cntn6 cnv cnvs ctnnb1 etiologically filtered focad german germline hsph1 kiaa1797 kif26b mining mutyh ngs nonrecurrent polyposis predispose predisposition prioritized stringent truncating uncover unexplained ybey	1379delt affecting caucasian encoded fibroma hpt hyperparathyroidism hystologically instrumental jaw jt l460lfs mandible modelling moiety mtt ossifying parafibromin parathyroid partners proband pth relatives sanger sca terminus underlie vast
Tagcloud (Intersection) ?		silico