MCM3AP and SUV39H2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MCM3AP	SUV39H2
Description		minichromosome maintenance complex component 3 associated protein	SUV39H2 histone lysine methyltransferase
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Membrane Protein-containing Complex Nuclear Pore Nuclear Basket Transcription Export Complex 2	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome
	Molecular Function	Nucleic Acid Binding Chromatin Binding Histone Acetyltransferase Activity Protein Binding Histone H3 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone Binding	Transcription Cis-regulatory Region Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity S-adenosyl-L-methionine Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Immune System Process MRNA Export From Nucleus Protein Transport Somatic Hypermutation Of Immunoglobulin Genes Poly(A)+ MRNA Export From Nucleus Nucleosome Organization MRNA Transport	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Circadian Rhythm Cell Differentiation Methylation Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Hypoxia
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Monocyte percentage of white cells ( 32888494) Periodontitis ( 30218097) Testicular germ cell tumor ( 23666240 25877299 28604728)	Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		19 interacting genes: APC CDC25A CDC42 CDC73 CLSTN1 CRMP1 ENY2 EP300 FAM118B MCM3 NUDT5 POLR2G RAC1 SMAD3 SMAD9 SUV39H2 TAF1D TMEM216 TSC22D1	43 interacting genes: AKAP9 APPL2 AR BLZF1 C8orf74 CBX7 CDCA4 CEP70 CFAP100 CGGBP1 EWSR1 FAM20C GOLGA6L9 GSTCD H3C1 ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MAGEA11 MCM3AP MRFAP1 MTF2 MYL12A NME4 ODAD3 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 VHL WIZ ZNF212 ZNF557 ZNF57
Entrez ID		8888	79723
HPRD ID		04483	07580
Ensembl ID		ENSG00000160294	ENSG00000152455
Uniprot IDs		O60318	Q9H5I1
PDB IDs		4DHX	2R3A 6P0R
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Leading Edge Membrane Wnt Signaling Pathway Nucleus Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly SMAD Protein Complex Heteromeric SMAD Protein Complex Positive Regulation Of Pseudopodium Assembly Protein Kinase Binding I-SMAD Binding Beta-catenin Binding Positive Regulation Of Cellular Component Biogenesis Regulation Of Stress Fiber Assembly Regulation Of Cell Junction Assembly Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Junction Assembly GTP-dependent Protein Binding Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Synapse Organization Regulation Of Primary Metabolic Process Positive Regulation Of Cell-substrate Adhesion SMAD Protein Signal Transduction Positive Regulation Of Lamellipodium Assembly Regulation Of Postsynapse Organization Phagocytosis, Engulfment Positive Regulation Of Focal Adhesion Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lamellipodium Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Nucleoplasm Cell Surface Receptor Signaling Pathway Regulation Of Supramolecular Fiber Organization Cytosol Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Growth Regulation Of Lamellipodium Assembly	Nucleoplasm Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3K36me3 Reader Activity Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
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