MCM3AP and SUV39H2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MCM3AP	SUV39H2
Gene Name		minichromosome maintenance complex component 3 associated protein	suppressor of variegation 3-9 homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Chromosome, Centromeric Region Chromatin Nucleoplasm Nuclear Heterochromatin
	Molecular Function	DNA Binding Transferase Activity, Transferring Acyl Groups	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)
	Biological Process	Immune System Process DNA Replication Protein Import Into Nucleus MRNA Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Assembly Or Disassembly Chromatin Remodeling Transcription, DNA-templated Male Meiosis Cell Differentiation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		19 interactors: APC CDC25A CDC42 CDC73 CLSTN1 CRMP1 ENY2 EP300 FAM118B MCM3 NUDT5 POLR2G RAC1 SMAD3 SMAD9 SUV39H2 TAF1D TMEM216 TSC22D1	39 interactors: AKAP9 APPL2 BLZF1 C8orf74 CBX5 CBX7 CCDC151 CCDC37 CDCA4 CEP70 CGGBP1 EWSR1 FAM20C GSTCD ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MCM3AP MRFAP1 MTF2 MYL12A NME4 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 WIZ ZNF212 ZNF557 ZNF57
Entrez ID		8888	79723
HPRD ID		04483	07580
Ensembl ID		ENSG00000160294	ENSG00000152455
Uniprot IDs		O60318	Q9H5I1
PDB IDs		4DHX	2R3A
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Stability Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Cell-cell Junction Organization Posttranscriptional Regulation Of Gene Expression RNA Biosynthetic Process Anatomical Structure Morphogenesis Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Cell Cycle DNA-templated Transcription, Elongation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Pseudopodium Assembly Regulation Of Cell Cycle Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of MRNA 3'-end Processing Response To Hypoxia Positive Regulation Of Cell Death Chromosome Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of MRNA 3'-end Processing Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Projection Assembly Epithelium Development Response To Abiotic Stimulus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Positive Regulation Of Cell Adhesion Tissue Development Biosynthetic Process Histone Modification Stem Cell Maintenance Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Wnt Signaling Pathway Cell Development	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Cellular Process Positive Regulation Of Histone H3-K27 Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Histone H3-K27 Methylation Regulation Of RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Osteoblast Differentiation Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Golgi To Plasma Membrane Transport Positive Regulation Of Histone Methylation Nitrogen Compound Metabolic Process Positive Regulation Of DNA Metabolic Process Osteoclast Maturation Regulation Of Histone Methylation Regulation Of Ossification Protein Targeting Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Establishment Of Protein Localization To Membrane Positive Regulation Of DNA Replication Positive Regulation Of Histone Modification Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Osteoblast Differentiation Myeloid Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization To Plasma Membrane Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition
Tagcloud ?		adenomatous arhgap causative cntn6 cnv cnvs ctnnb1 etiologically filtered focad german germline hsph1 kiaa1797 kif26b mining mutyh ngs nonrecurrent polyposis predispose predisposition prioritized silico stringent truncating uncover unexplained ybey	a7 circular dichroism dim g12 g13 g9a h3k9 h3k9me0 h3k9me1 h3k9me2 h3k9me3 introduce introduces k14 labrador n324k pkmts prefers processive r8 readout recognizes renders retrievers s10 t11 t6
Tagcloud (Difference) ?		adenomatous arhgap causative cntn6 cnv cnvs ctnnb1 etiologically filtered focad german germline hsph1 kiaa1797 kif26b mining mutyh ngs nonrecurrent polyposis predispose predisposition prioritized silico stringent truncating uncover unexplained ybey	a7 circular dichroism dim g12 g13 g9a h3k9 h3k9me0 h3k9me1 h3k9me2 h3k9me3 introduce introduces k14 labrador n324k pkmts prefers processive r8 readout recognizes renders retrievers s10 t11 t6
Tagcloud (Intersection) ?