MCM3AP and ENY2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		MCM3AP	ENY2
Description		minichromosome maintenance complex component 3 associated protein	ENY2 transcription and export complex 2 subunit
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Membrane Protein-containing Complex Nuclear Pore Nuclear Basket Transcription Export Complex 2	SAGA Complex Nucleus Nuclear Pore Nucleoplasm Mitochondrion Transcription Factor TFTC Complex Nuclear Pore Nuclear Basket Transcription Export Complex 2 DUBm Complex
	Molecular Function	Nucleic Acid Binding Chromatin Binding Histone Acetyltransferase Activity Protein Binding Histone H3 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone Binding	Chromatin Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Immune System Process MRNA Export From Nucleus Protein Transport Somatic Hypermutation Of Immunoglobulin Genes Poly(A)+ MRNA Export From Nucleus Nucleosome Organization MRNA Transport	Regulation Of DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II MRNA Export From Nucleus Protein Transport Poly(A)+ MRNA Export From Nucleus Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription MRNA Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Pathways			HATs acetylate histones
Drugs
Diseases
GWAS		Monocyte percentage of white cells ( 32888494) Periodontitis ( 30218097) Testicular germ cell tumor ( 23666240 25877299 28604728)	Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Night sleep phenotypes ( 27126917)
Interacting Genes		19 interacting genes: APC CDC25A CDC42 CDC73 CLSTN1 CRMP1 ENY2 EP300 FAM118B MCM3 NUDT5 POLR2G RAC1 SMAD3 SMAD9 SUV39H2 TAF1D TMEM216 TSC22D1	7 interacting genes: APP ATXN7L3B CEBPA CSTPP1 HNRNPA2B1 MCM3AP UFL1
Entrez ID		8888	56943
HPRD ID		04483	13121
Ensembl ID		ENSG00000160294	ENSG00000120533
Uniprot IDs		O60318	Q9NPA8
PDB IDs		4DHX	4DHX
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Leading Edge Membrane Wnt Signaling Pathway Nucleus Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly SMAD Protein Complex Heteromeric SMAD Protein Complex Positive Regulation Of Pseudopodium Assembly Protein Kinase Binding I-SMAD Binding Beta-catenin Binding Positive Regulation Of Cellular Component Biogenesis Regulation Of Stress Fiber Assembly Regulation Of Cell Junction Assembly Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Junction Assembly GTP-dependent Protein Binding Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Synapse Organization Regulation Of Primary Metabolic Process Positive Regulation Of Cell-substrate Adhesion SMAD Protein Signal Transduction Positive Regulation Of Lamellipodium Assembly Regulation Of Postsynapse Organization Phagocytosis, Engulfment Positive Regulation Of Focal Adhesion Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lamellipodium Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Nucleoplasm Cell Surface Receptor Signaling Pathway Regulation Of Supramolecular Fiber Organization Cytosol Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Growth Regulation Of Lamellipodium Assembly	Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Protein-containing Complex Organization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Intermediate-density Lipoprotein Particle Positive Regulation Of Inflammatory Response Regulation Of Cell Activation Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Protein Catabolic Process Protein-containing Complex Regulation Of Inflammatory Response Lipoprotein Particle Memory Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Metal Ion Low-density Lipoprotein Particle Mediated Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Nuclear Matrix RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 White Fat Cell Proliferation
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