SGPL1 and ERG28

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGPL1	ERG28
Description		sphingosine-1-phosphate lyase 1	ergosterol biosynthesis 28 homolog
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Transport Vesicle
	Molecular Function	Protein Binding Sphinganine-1-phosphate Aldolase Activity Lyase Activity Carbon-carbon Lyase Activity Pyridoxal Phosphate Binding	Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding
	Biological Process	Luteinization Vasculogenesis Kidney Development Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Apoptotic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Fibroblast Migration Carboxylic Acid Metabolic Process Hemopoiesis Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Sterol Biosynthetic Process
Pathways		Sphingolipid catabolism
Drugs		Pyridoxal phosphate
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		34 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TSPAN4 UNC50	127 interacting genes: ALDH2 ANXA1 ANXA7 AQP2 AQP3 AQP6 ARL13B BAIAP2 BCL2L13 BID BTBD2 CCDC106 CCL18 CD53 CD74 CDC42 CDK5RAP2 CELF3 CLDN5 CLDN7 CLN8 COX17 COXFA4L2 CRADD CREB1 CREB3 CREB3L1 CSTF2 CYB561 DYNLL1 EBP ELOVL4 ERBB2 ERBB3 ERBB4 ERGIC3 FAM174A FAM209A FAS FCGR2B FFAR2 FXR1 FXYD3 GADD45A GET1 GJB5 GPR152 GPR37L1 GPR42 GPX8 GSK3B HMGB1 HNRNPH3 HNRNPUL1 HSD17B11 HSPE1 HTR2C HYLS1 JAGN1 KCNJ6 KLHL20 LHFPL5 LMNA LSM2 LYPD5 MAPK8IP2 MGST3 MPHOSPH6 MRM1 MRPL38 MRPS12 MS4A3 MSMO1 MTERF3 MTNR1B MUC1 NAT9 NCR3LG1 NDUFA3 NR1H2 NSDHL NSF PAFAH1B3 PCDHA4 PDZK1IP1 PEX2 PFN1 PHYHIP PIGY POLE2 POLR2C POLR3F PPP1R8 PQBP1 PSCA RAB27A REEP4 RETREG3 RPS6KA6 S100A8 SAR1A SAT1 SEPHS1 SERPINB9 SGPL1 SLC10A6 SLC26A6 SLC34A2 SLC71A2 SNRPB SNRPG SSMEM1 STOM STX1A SULT1E1 TFG TK1 TLCD4 TM4SF19 TMEM106A TMEM222 TMEM31 TMPRSS2 TSC22D1 TTR ZFP64 ZNF24
Entrez ID		8879	11161
HPRD ID		07224	05201
Ensembl ID		ENSG00000166224	ENSG00000133935
Uniprot IDs		A0A8V8TN35 O95470	Q6FII3 Q86TW5 Q9UKR5
PDB IDs		4Q6R 8AYF
Enriched GO Terms of Interacting Partners?		Membrane Channel Activity Water Channel Activity Water Transport Plasma Membrane Glycerol Channel Activity Fluid Transport Urea Transmembrane Transporter Activity Glycerol Transmembrane Transport Basolateral Plasma Membrane Polyol Transmembrane Transport Urea Transmembrane Transport R-loop Processing Positive Regulation Of CGAS/STING Signaling Pathway Urea Transport	Protein Binding Membrane Identical Protein Binding Negative Regulation Of Apoptotic Process Renal Water Transport Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Polyol Transmembrane Transport Regulation Of Apoptotic Process Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Regulation Of Secretion Regulation Of Programmed Cell Death Endoplasmic Reticulum Membrane Regulation Of MAPK Cascade Fluid Transport Water Channel Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Viral Entry Into Host Cell Neuregulin Receptor Activity Regulation Of Transport Negative Regulation Of Hemopoiesis Negative Regulation Of Secretion Apolipoprotein A-I Receptor Binding Regulation Of Protein-containing Complex Assembly Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Peptide Secretion Apical Plasma Membrane Positive Regulation Of Transport
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