SGPL1 and TSPAN4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGPL1	TSPAN4
Description		sphingosine-1-phosphate lyase 1	tetraspanin 4
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Focal Adhesion Membrane Vesicle
	Molecular Function	Protein Binding Sphinganine-1-phosphate Aldolase Activity Lyase Activity Carbon-carbon Lyase Activity Pyridoxal Phosphate Binding	Antigen Binding Integrin Binding Protein Binding
	Biological Process	Luteinization Vasculogenesis Kidney Development Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Apoptotic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Fibroblast Migration Carboxylic Acid Metabolic Process Hemopoiesis Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway	Protein-containing Complex Assembly
Pathways		Sphingolipid catabolism
Drugs		Pyridoxal phosphate
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Falling risk ( 32999390)
Interacting Genes		34 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TSPAN4 UNC50	49 interacting genes: CATSPER1 CD46 CD81 CD9 CHRD CLDN11 CLEC2D CREB3 CREB5 CYSRT1 EVA1A FCHO1 FRS3 GNE GRN GUCD1 HOXA1 ITGA3 ITGA6 ITGB1 KRTAP10-1 KRTAP10-8 KRTAP4-11 KRTAP4-5 KRTAP6-2 KRTAP9-2 KRTAP9-3 LCE1A LCE2B LCE2D LCE3A LCE3C LCE3D LCE4A LRRC25 LTB4R2 MDFI MGAT5B MKRN3 NBPF19 NOTCH2NLA NR4A3 OTX1 PHLDA1 PLSCR4 SGPL1 TEKT4 TMEM106A VGLL3
Entrez ID		8879	7106
HPRD ID		07224	04033
Ensembl ID		ENSG00000166224	ENSG00000214063
Uniprot IDs		A0A8V8TN35 O95470	A8MVV6 O14817
PDB IDs		4Q6R 8AYF
Enriched GO Terms of Interacting Partners?		Membrane Channel Activity Water Channel Activity Water Transport Plasma Membrane Glycerol Channel Activity Fluid Transport Urea Transmembrane Transporter Activity Glycerol Transmembrane Transport Basolateral Plasma Membrane Polyol Transmembrane Transport Urea Transmembrane Transport R-loop Processing Positive Regulation Of CGAS/STING Signaling Pathway Urea Transport	Keratinization Epidermis Development Keratin Filament Intermediate Filament Integrin Alpha6-beta1 Complex Integrin Alpha3-beta1 Complex Myoblast Fusion Involved In Skeletal Muscle Regeneration Myoblast Fusion Integrin Complex Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Lipoprotein Particle Stimulus Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Cerebellar Climbing Fiber To Purkinje Cell Synapse Identical Protein Binding CAMP Response Element Binding Regulation Of Cell Motility Hair Cycle Regulation Of Locomotion Integrin Binding Mesodermal Cell Differentiation Tissue Development
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