SGPL1 and RNASE10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGPL1	RNASE10
Description		sphingosine-1-phosphate lyase 1	ribonuclease A family member 10 (inactive)
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Extracellular Region
	Molecular Function	Protein Binding Sphinganine-1-phosphate Aldolase Activity Lyase Activity Carbon-carbon Lyase Activity Pyridoxal Phosphate Binding	Nucleic Acid Binding RNA Nuclease Activity Protein Binding
	Biological Process	Luteinization Vasculogenesis Kidney Development Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Apoptotic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Fibroblast Migration Carboxylic Acid Metabolic Process Hemopoiesis Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway	Cell Adhesion Single Fertilization Positive Regulation Of Cell-cell Adhesion Heterotypic Cell-cell Adhesion Defense Response To Gram-positive Bacterium Regulation Of Fertilization Positive Regulation Of Flagellated Sperm Motility
Pathways		Sphingolipid catabolism
Drugs		Pyridoxal phosphate
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Immune response to measles-mumps-rubella vaccine ( 24811271)
Interacting Genes		34 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TSPAN4 UNC50	6 interacting genes: BFSP2 CREB3L1 MRM1 SGPL1 SGTA SGTB
Entrez ID		8879	338879
HPRD ID		07224	18495
Ensembl ID		ENSG00000166224	ENSG00000182545
Uniprot IDs		A0A8V8TN35 O95470	Q5GAN6 W0UTC4
PDB IDs		4Q6R 8AYF
Enriched GO Terms of Interacting Partners?		Membrane Channel Activity Water Channel Activity Water Transport Plasma Membrane Glycerol Channel Activity Fluid Transport Urea Transmembrane Transporter Activity Glycerol Transmembrane Transport Basolateral Plasma Membrane Polyol Transmembrane Transport Urea Transmembrane Transport R-loop Processing Positive Regulation Of CGAS/STING Signaling Pathway Urea Transport	TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Negative Regulation Of Response To Endoplasmic Reticulum Stress Protein Targeting To Membrane Sphinganine-1-phosphate Aldolase Activity Regulation Of Response To Endoplasmic Reticulum Stress RRNA (guanosine-2'-O-)-methyltransferase Activity RRNA (guanine) Methyltransferase Activity RRNA 2'-O-methylation Extracellular Matrix Constituent Secretion BAT3 Complex Binding Molecular Adaptor Activity Establishment Of Protein Localization To Membrane Protein Targeting Negative Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Lens Fiber Cell Development Luteinization Carbon-carbon Lyase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?