SGPL1 and TMEM173

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		SGPL1	TMEM173
Gene Name		sphingosine-1-phosphate lyase 1	transmembrane protein 173
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Mitochondrial Outer Membrane Peroxisome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Sphinganine-1-phosphate Aldolase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding	Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Identical Protein Binding Protein Homodimerization Activity Cyclic-GMP-AMP Binding
	Biological Process	Luteinization Vasculogenesis Kidney Development Fatty Acid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Fibroblast Migration Hemopoiesis Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Small Molecule Metabolic Process Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Palate Development Face Morphogenesis Apoptotic Signaling Pathway	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Apoptotic Process Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-beta Production Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Positive Regulation Of Transcription Factor Import Into Nucleus Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Cellular Response To Exogenous DsRNA
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis	Regulation of innate immune responses to cytosolic DNA ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN STAT6-mediated induction of chemokines Innate Immune System
Drugs		Pyridoxal Phosphate
Diseases
GWAS			Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		1 interactors: TMEM173	9 interactors: CCDC47 DDOST IRAK1 LTN1 MBOAT7 SGPL1 STT3A SURF4 TRIM32
Entrez ID		8879	340061
HPRD ID		07224	14173
Ensembl ID		ENSG00000166224
Uniprot IDs		O95470	Q86WV6
PDB IDs			4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI
Enriched GO Terms of Interacting Partners?		Interferon-beta Production Cellular Response To Exogenous DsRNA Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Type I Interferon Production Positive Regulation Of Defense Response To Virus By Host Response To Interferon-beta Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Defense Response To Virus By Host Cellular Response To DsRNA Positive Regulation Of Transcription Factor Import Into Nucleus Response To Exogenous DsRNA Positive Regulation Of Protein Binding Response To DsRNA Positive Regulation Of Type I Interferon Production Regulation Of Defense Response To Virus Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Regulation Of Type I Interferon Production Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Binding Cytokine Production Activation Of Innate Immune Response Regulation Of Protein Binding Defense Response To Virus Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of Innate Immune Response Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Transport Regulation Of Innate Immune Response Regulation Of Binding Response To Virus Regulation Of Intracellular Protein Transport Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Cellular Response To Organic Cyclic Compound Regulation Of Intracellular Transport Regulation Of Cytokine Production
Tagcloud ?		181b augment bioactive bowel cac chemically colitis colon colonic cyld cylindromatosis degrades enterocytes incompletely irreversibly lyase metabolized micrornas s1p shortening sphingadienes sphingolipid sphingolipids sphingosine spinster spl spns2 stat3 tumorigenic	advantage antibacterial autophagic autophagosome autophagy causative colocalizes connected cytosolic defense dram1 flux immunity marinum modulator mycobacterium myd88 nfkb p62 pathogen protects sensor sqstm1 sting summarize tlr toll took zebrafish
Tagcloud (Difference) ?		181b augment bioactive bowel cac chemically colitis colon colonic cyld cylindromatosis degrades enterocytes incompletely irreversibly lyase metabolized micrornas s1p shortening sphingadienes sphingolipid sphingolipids sphingosine spinster spl spns2 stat3 tumorigenic	advantage antibacterial autophagic autophagosome autophagy causative colocalizes connected cytosolic defense dram1 flux immunity marinum modulator mycobacterium myd88 nfkb p62 pathogen protects sensor sqstm1 sting summarize tlr toll took zebrafish
Tagcloud (Intersection) ?