SGPL1 and PAQR5

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SGPL1	PAQR5
Name		sphingosine-1-phosphate lyase 1	progestin and adipoQ receptor family member 5
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Sphinganine-1-phosphate Aldolase Activity Lyase Activity Carbon-carbon Lyase Activity Pyridoxal Phosphate Binding	Steroid Binding Protein Binding Lipid Binding Signaling Receptor Activity
	Biological Process	Luteinization Vasculogenesis Kidney Development Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Apoptotic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Fibroblast Migration Carboxylic Acid Metabolic Process Hemopoiesis Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway	Cell Differentiation Oogenesis
Pathways		Sphingolipid catabolism	None
Drugs		Pyridoxal phosphate	None
GWAS		High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Metabolite levels ( 23823483 ) Microalbuminuria ( 26631737 ) Red cell distribution width ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )	Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Calcium levels ( 29403010 ) Diastolic blood pressure ( 27841878 ) Systolic blood pressure ( 30578418 )
Novel Interactors		2 novel interactors: ANK3 DDX21	None recorded
Interacting Genes		34 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TSPAN4 UNC50	7 interacting genes: ERGIC3 GPX8 IGSF9 IL3RA LMNA SGPL1 SYNE4
Entrez ID		8879	54852
HPRD ID		07224	08475
Ensembl ID		ENSG00000166224	ENSG00000137819
Uniprot IDs		A0A8V8TN35 O95470	Q9NXK6
PDB IDs		4Q6R 8AYF	Not available
GO Terms Enriched among Interactors		Membrane Channel Activity Water Channel Activity Water Transport Plasma Membrane Glycerol Channel Activity Fluid Transport Urea Transmembrane Transporter Activity Glycerol Transmembrane Transport Basolateral Plasma Membrane Polyol Transmembrane Transport Urea Transmembrane Transport R-loop Processing Positive Regulation Of CGAS/STING Signaling Pathway Urea Transport	None