MEIS2 and TRIM25

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		MEIS2	TRIM25
Gene Name		Meis homeobox 2	tripartite motif containing 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Eye Development Transcription From RNA Polymerase II Promoter Response To Mechanical Stimulus Pancreas Development Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor	Viral Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell
Pathways			Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Interferon gamma signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System
Drugs
Diseases
GWAS		Hyperactive-impulsive symptoms ( 18821565) Response to antipsychotic treatment ( 20195266)	Height ( 18391951)
Protein-Protein Interactions		14 interactors: ANXA1 APP ARNT2 C1orf94 CRBN DGCR6 HOXA13 HOXA9 LINC00238 OSGIN1 PBX1 SQSTM1 TRIM25 ZNHIT3	27 interactors: AMFR DDX58 ERCC2 ESR1 GATA1 GRIK2 MEIS2 OTUB2 PITX2 RARRES3 RBCK1 RNF31 SFN STK38 TFG TRAF6 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L6 UBE2N USP15 USP39 ZNF24
Entrez ID		4212	7706
HPRD ID		03443	02711
Ensembl ID		ENSG00000134138	ENSG00000121060
Uniprot IDs		B3KPD8 B7Z6F6 O14770	Q14258
PDB IDs		3K2A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Embryonic Limb Morphogenesis Regulation Of Cell Cycle Process Gland Development Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Limb Development Response To Estrogen Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Death Regulation Of G2/M Transition Of Mitotic Cell Cycle Developmental Process Regulation Of Cell Cycle G2/M Phase Transition Proximal/distal Pattern Formation Organ Development Regulation Of Transcription, DNA-templated Embryonic Forelimb Morphogenesis Positive Regulation Of Transcription, DNA-templated Reproductive Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Immune System Process Developmental Process Involved In Reproduction Regulation Of RNA Metabolic Process Forelimb Morphogenesis Sex Differentiation Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Neutrophil Clearance Prostate Gland Development Multicellular Organismal Development Positive Regulation Of Gene Expression Regulation Of Cell Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Urogenital System Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Neutrophil Apoptotic Process Synaptic Growth At Neuromuscular Junction	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Organic Substance Activation Of Innate Immune Response Proteolysis Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K48-linked Ubiquitination Toll-like Receptor Signaling Pathway Immune System Process Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Signaling Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Proteasomal Protein Catabolic Process Cell Communication Response To Stimulus Cellular Response To Stimulus Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction Cellular Metabolic Process Negative Regulation Of Gene Expression MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription, DNA-templated Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Substance
Tagcloud ?		accumulative aldehyde aldh1a1 blots cbfb cxcl6 devastating diras diras3 feel glaucoma homeobox identifiable immunocytochemistry meshwork negatives pitx2 protocols pursued ranking samd5 sirnas statistic sterile subtle tm tms vis	accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitin ubiquitylates ubiquitylation uncovers vital
Tagcloud (Difference) ?		accumulative aldehyde aldh1a1 blots cbfb cxcl6 devastating diras diras3 feel glaucoma homeobox identifiable immunocytochemistry meshwork negatives pitx2 protocols pursued ranking samd5 sirnas statistic sterile subtle tm tms vis	accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitin ubiquitylates ubiquitylation uncovers vital
Tagcloud (Intersection) ?