MEIS2 and HOXA13

Number of citations of the paper that reports this interaction (PubMedID 15617687)
0

Data Source:
HPRD (two hybrid)

		MEIS2	HOXA13
Description		Meis homeobox 2	homeobox A13
Image
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Chromosome Intermediate Filament Cytoskeleton
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Regulation Of DNA-templated Transcription Brain Development Positive Regulation Of Cell Population Proliferation Visual Learning Response To Mechanical Stimulus Embryonic Pattern Specification Animal Organ Morphogenesis Pancreas Development Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Positive Regulation Of Cardiac Muscle Myoblast Proliferation	Skeletal System Development Vasculogenesis Endothelial Cell Morphogenesis Tissue Homeostasis Ventricular Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of BMP Signaling Pathway Male Genitalia Development Prostate Gland Development Response To Testosterone Embryonic Forelimb Morphogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Embryonic Hindgut Morphogenesis Inner Ear Development Artery Morphogenesis Branching Involved In Prostate Gland Morphogenesis Endothelial Cell Fate Specification Mesenchymal Cell Apoptotic Process Mitotic Nuclear Division Positive Regulation Of Mesenchymal Cell Apoptotic Process
Pathways
Drugs
Diseases			Hand-foot-genital syndrome Guttmacher syndrome
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Hyperactive-impulsive symptoms ( 18821565) Intraocular pressure ( 24002674) Major depressive disorder ( 27479909) Post bronchodilator FEV1 in COPD ( 26634245) Postprandial triglyceride response ( 32603185) Response to antipsychotic treatment ( 20195266) Restless legs syndrome ( 29029846) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)	Hepatitis B surface antigen seroclearance in chronic hepatitis B infection ( 29975729) Metabolite levels ( 23823483)
Interacting Genes		50 interacting genes: ADRA2C ANTKMT ANXA1 APP ARNT2 BPIFA1 C1orf94 CARTPT CCDC196 CTAG1A CTAG1B DGCR6 DRD1 FAM136A FAM168A HOXA13 HOXA9 IGFBP6 ITGB3BP KRTAP10-8 KRTAP11-1 KRTAP13-1 KRTAP19-2 KRTAP19-6 KRTAP22-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 MCCD1 NDUFB7 NOTO NUP58 OIP5 OSGIN1 PBX1 POU2AF1 POU6F2 PTK6 RBPMS RUSC1 SCT SPMIP6 SQSTM1 TBX2 TIMM10B TLX1 TRIM25 TRIM42 VGLL1 ZNHIT3	6 interacting genes: MEIS1 MEIS2 MEIS3 SMAD1 SMAD2 SMAD5
Entrez ID		4212	3209
HPRD ID		03443	00847
Ensembl ID		ENSG00000134138	ENSG00000106031
Uniprot IDs		B3KPD8 B7Z6F6 O14770	P31271 Q6DI00
PDB IDs		3K2A 4XRM 5BNG 5EG0	2L7Z
Enriched GO Terms of Interacting Partners?		Intermediate Filament Positive Regulation Of Long-term Synaptic Potentiation	Embryonic Pattern Specification Pattern Specification Process SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Homomeric SMAD Protein Complex Positive Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Osteoblast Fate Commitment Animal Organ Development Anatomical Structure Morphogenesis Mesonephric Tubule Development Mesonephric Epithelium Development Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anti-Mullerian Hormone Receptor Signaling Pathway Kidney Epithelium Development Positive Regulation Of RNA Metabolic Process Response To Growth Factor Positive Regulation Of Nucleobase-containing Compound Metabolic Process DEAD/H-box RNA Helicase Binding DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transforming Growth Factor Beta Receptor Signaling Pathway Co-SMAD Binding Sequence-specific DNA Binding Eye Development Primary MiRNA Processing Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Cardiac Conduction System Development Animal Organ Morphogenesis Positive Regulation Of Biosynthetic Process Sensory Organ Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Differentiation Pancreas Development Negative Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Tube Development Epithelium Development
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