MEIS2 and HOXA9

Number of citations of the paper that reports this interaction (PubMedID 15161102)
0

Data Source:
HPRD (in vitro)

		MEIS2	HOXA9
Description		Meis homeobox 2	homeobox A9
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Regulation Of DNA-templated Transcription Brain Development Positive Regulation Of Cell Population Proliferation Visual Learning Response To Mechanical Stimulus Embryonic Pattern Specification Animal Organ Morphogenesis Pancreas Development Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Positive Regulation Of Cardiac Muscle Myoblast Proliferation	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Single Fertilization Male Gonad Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Regulation Of Gene Expression Prostate Gland Development Mammary Gland Development Response To Testosterone Embryonic Forelimb Morphogenesis Endothelial Cell Activation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Uterus Development Definitive Hemopoiesis
Pathways
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Hyperactive-impulsive symptoms ( 18821565) Intraocular pressure ( 24002674) Major depressive disorder ( 27479909) Post bronchodilator FEV1 in COPD ( 26634245) Postprandial triglyceride response ( 32603185) Response to antipsychotic treatment ( 20195266) Restless legs syndrome ( 29029846) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)	A body shape index ( 34021172) Hypertension ( 30487518) Mean arterial pressure ( 30487518) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		50 interacting genes: ADRA2C ANTKMT ANXA1 APP ARNT2 BPIFA1 C1orf94 CARTPT CCDC196 CTAG1A CTAG1B DGCR6 DRD1 FAM136A FAM168A HOXA13 HOXA9 IGFBP6 ITGB3BP KRTAP10-8 KRTAP11-1 KRTAP13-1 KRTAP19-2 KRTAP19-6 KRTAP22-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 MCCD1 NDUFB7 NOTO NUP58 OIP5 OSGIN1 PBX1 POU2AF1 POU6F2 PTK6 RBPMS RUSC1 SCT SPMIP6 SQSTM1 TBX2 TIMM10B TLX1 TRIM25 TRIM42 VGLL1 ZNHIT3	18 interacting genes: CREBBP CUL4A EIF4E JUN KRTAP10-1 KRTAP9-3 MEIS1 MEIS2 NFKBIA PBX1 PBX2 PBX3 PLSCR1 RBPMS SMAD2 SMAD4 TMEM132D TRIP6
Entrez ID		4212	3205
HPRD ID		03443	00844
Ensembl ID		ENSG00000134138	ENSG00000078399
Uniprot IDs		B3KPD8 B7Z6F6 O14770	P31269
PDB IDs		3K2A 4XRM 5BNG 5EG0
Enriched GO Terms of Interacting Partners?		Intermediate Filament Positive Regulation Of Long-term Synaptic Potentiation	Transcription Regulator Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II SMAD Protein Signal Transduction Pattern Specification Process Eye Development Negative Regulation Of Cell Differentiation Chromatin Embryonic Pattern Specification Animal Organ Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Sensory Organ Development Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Developmental Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Myeloid Cell Differentiation R-SMAD Binding Activin Responsive Factor Complex Brain Development Anatomical Structure Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regionalization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Regulation Of Primary Metabolic Process SMAD Protein Complex Anterior/posterior Pattern Specification Heteromeric SMAD Protein Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity Animal Organ Development Negative Regulation Of Neuron Differentiation Embryonic Morphogenesis Regulation Of Myeloid Cell Differentiation Nucleus
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