MBP and PPP2R5C

Number of citations of the paper that reports this interaction (PMID 15380617)
16

Data Source:
BioGRID (enzymatic study)

		MBP	PPP2R5C
Gene Name		myelin basic protein	protein phosphatase 2, regulatory subunit B, gamma
Image
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Internode Region Of Axon Neuronal Cell Body Compact Myelin	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus
	Molecular Function	Protease Binding Protein Binding Structural Constituent Of Myelin Sheath	Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process	Immune Response Synaptic Transmission Central Nervous System Development Aging Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Response To Progesterone Response To Tumor Necrosis Factor Myelination Response To Mercury Ion Negative Regulation Of Axonogenesis Membrane Organization Response To Fatty Acid	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity
Pathways			Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Mitotic Anaphase Signaling by Wnt M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling CTLA4 inhibitory signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Cell Cycle, Mitotic Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration (GA) ( 22705344)	Autism ( 20663923)
Protein-Protein Interactions		72 interactors: ABL1 APTX ATN1 ATXN1 BMP2K CCNC CCNH CCNT1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 DYRK1B HIPK2 HLA-DRA IKBKE IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPKAPK5 MELK MICU2 MKNK1 MMP7 MNAT1 NEK9 PAK1 PKN1 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1	14 interactors: APP AXIN1 BRCA1 CHEK2 EP300 IER3 MAPK1 MBP PAXIP1 PPP2CA PPP2R1B PRKCD PXN SGOL1
Entrez ID		4155	5527
HPRD ID		01158	03385
Ensembl ID		ENSG00000197971	ENSG00000078304
Uniprot IDs		P02686	Q13362
PDB IDs		1BX2 1FV1 1HQR 1QCL 1YMM 1ZGL	2IAE 2JAK 2NPP 2NYL 2NYM 3FGA
Enriched GO Terms of Interacting Partners?		Protein Phosphorylation Phosphorylation Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Intracellular Signal Transduction Regulation Of Protein Phosphorylation Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Signal Transduction By Phosphorylation Protein Autophosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Protein Kinase Activity Peptidyl-threonine Phosphorylation Cellular Response To Growth Factor Stimulus Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway MAPK Cascade Cellular Response To Stress Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Response To Stimulus Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Death Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Response To Stimulus Regulation Of MAP Kinase Activity Apoptotic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cellular Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Developmental Process Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Cell Cycle Regulation Of Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Regulation Of Signaling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Stability Apoptotic Signaling Pathway Cellular Protein Modification Process Signaling Regulation Of Protein Kinase Activity Cell Communication Regulation Of Kinase Activity Regulation Of Cellular Component Organization Positive Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Posttranscriptional Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Signal Transduction Cell Cycle Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Anatomical Structure Morphogenesis Response To Abiotic Stimulus Cellular Protein Metabolic Process Protein Stabilization Signal Transduction In Response To DNA Damage Positive Regulation Of Histone H3-K4 Methylation
Tagcloud ?		ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad	3beta annexin ataxia atm cck downregulated efficient glycogen gsk homolog interference jurkat leukemias leukemic mdm2 molt nonsilencing nucleofection pi qrt scrambled sirna sirna2 sirnas tcr telangiectasia transfected treat twofold
Tagcloud (Difference) ?		ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad	3beta annexin ataxia atm cck downregulated efficient glycogen gsk homolog interference jurkat leukemias leukemic mdm2 molt nonsilencing nucleofection pi qrt scrambled sirna sirna2 sirnas tcr telangiectasia transfected treat twofold
Tagcloud (Intersection) ?