MBP and DYRK1B

Number of citations of the paper that reports this interaction (PMID 10910078)
28

Data Source:
HPRD (in vitro)

		MBP	DYRK1B
Gene Name		myelin basic protein	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Internode Region Of Axon Neuronal Cell Body Compact Myelin	Nucleus
	Molecular Function	Protease Binding Protein Binding Structural Constituent Of Myelin Sheath	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Immune Response Synaptic Transmission Central Nervous System Development Aging Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Response To Progesterone Response To Tumor Necrosis Factor Myelination Response To Mercury Ion Negative Regulation Of Axonogenesis Membrane Organization Response To Fatty Acid	Protein Phosphorylation Myoblast Fusion Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription, DNA-templated Adipose Tissue Development
Pathways
Drugs
Diseases
GWAS		Age-related macular degeneration (GA) ( 22705344)
Protein-Protein Interactions		72 interactors: ABL1 APTX ATN1 ATXN1 BMP2K CCNC CCNH CCNT1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 DYRK1B HIPK2 HLA-DRA IKBKE IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPKAPK5 MELK MICU2 MKNK1 MMP7 MNAT1 NEK9 PAK1 PKN1 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1	11 interactors: DCAF7 HDAC5 LZTS2 MAP2K3 MAPK1 MAPK14 MBP PAK1 PCBD1 RANBP9 TROAP
Entrez ID		4155	9149
HPRD ID		01158	05188
Ensembl ID		ENSG00000197971	ENSG00000105204
Uniprot IDs		P02686	B4DXU2 Q9Y463
PDB IDs		1BX2 1FV1 1HQR 1QCL 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?		Protein Phosphorylation Phosphorylation Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Intracellular Signal Transduction Regulation Of Protein Phosphorylation Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Signal Transduction By Phosphorylation Protein Autophosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Protein Kinase Activity Peptidyl-threonine Phosphorylation Cellular Response To Growth Factor Stimulus Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway MAPK Cascade Cellular Response To Stress Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Response To Stimulus Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Death Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Response To Stimulus Regulation Of MAP Kinase Activity Apoptotic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of MAP Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway MAPK Cascade Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Toll-like Receptor 4 Signaling Pathway Regulation Of MAP Kinase Activity Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Response To Peptide Positive Regulation Of Kinase Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Transferase Activity Cellular Response To Insulin Stimulus Chemotaxis Regulation Of MAPK Cascade Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Immune Response Immune Response Regulation Of Innate Immune Response Immune System Process Positive Regulation Of Transcription, DNA-templated Nucleocytoplasmic Transport Peptidyl-threonine Phosphorylation Nuclear Transport Multicellular Organismal Development Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Insulin Regulation Of Myotube Differentiation
Tagcloud ?		ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad	2a balance bm88 brdu bromo cend1 coordination cytosolic deoxyuridine destabilization elucidate exit incorporation lineage modulator neuro neuroblastoma neuronal partner pivotal precursors ran ranbpm retention reverted scaffolding stabilizes transiently
Tagcloud (Difference) ?		ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad	2a balance bm88 brdu bromo cend1 coordination cytosolic deoxyuridine destabilization elucidate exit incorporation lineage modulator neuro neuroblastoma neuronal partner pivotal precursors ran ranbpm retention reverted scaffolding stabilizes transiently
Tagcloud (Intersection) ?