ARHGEF7 and GIT2

Number of citations of the paper that reports this interaction (PubMedID 16628223)
42

Data Source:
HPRD (in vitro, in vivo)

		ARHGEF7	GIT2
Description		Rho guanine nucleotide exchange factor 7	GIT ArfGAP 2
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Centrosome Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Cell Projection Neuron Projection Neuronal Cell Body Anchoring Junction Mitotic Spindle Pole Postsynapse	Nucleoplasm Focal Adhesion Synapse Presynapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Gamma-tubulin Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Golgi Organization Signal Transduction Rho Protein Signal Transduction Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Microtubule Nucleation Positive Regulation Of Lamellipodium Morphogenesis	Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Synaptic Vesicle Recycling
Pathways		EGFR downregulation NRAGE signals death through JNK Ephrin signaling G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle	CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs
Diseases
GWAS		Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824) Weight ( 34074324)	Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)
Interacting Genes		37 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN FXR1 FXR2 GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PRRG4 PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 VHL WAS YWHAG	47 interacting genes: ACTG1 ACTN1 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG
Entrez ID		8874	9815
HPRD ID		05688	09779
Ensembl ID		ENSG00000102606	ENSG00000139436
Uniprot IDs		A0A2R8YG42 A0A8V8TQ72 B1ALK7 B7Z344 B7Z6G2 E9PDQ5 Q14155	F8VXI9 F8W822 Q14161 Q6FI58
PDB IDs		1BY1 1ZSG 2L3G 5SXP
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Stress Fiber Assembly Postsynapse Regulation Of Cell Communication Regulation Of Actin Cytoskeleton Organization Regulation Of Signal Transduction Regulation Of Actin Filament-based Process Cell-cell Junction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cytoskeleton Organization Signal Transduction Glutamatergic Synapse Positive Regulation Of Stress Fiber Assembly Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cytoskeleton Organization Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Plasma Membrane Modulation Of Chemical Synaptic Transmission Enzyme-linked Receptor Protein Signaling Pathway Cell Projection Small GTPase Binding SH3 Domain Binding Lamellipodium Regulation Of Synaptic Plasticity Cytosol Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Dendrite Neuron Projection Regulation Of Organelle Organization Cytoplasm Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Organelle Organization Protein Localization To Cell Junction Postsynaptic Density Positive Regulation Of T Cell Tolerance Induction Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Regulation Of Locomotion	Identical Protein Binding Cytosol Regulation Of Supramolecular Fiber Organization Cytoplasm Focal Adhesion Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Ephrin Receptor Signaling Pathway Cell-cell Junction Regulation Of Microtubule Nucleation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Organization Regulation Of Lung Blood Pressure Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament Cytoskeleton Gamma-tubulin Binding Actin Filament-based Process Response To Type II Interferon Regulation Of Intracellular Signal Transduction Ruffle Positive Regulation Of Microtubule Nucleation Regulation Of Canonical NF-kappaB Signal Transduction Postsynapse Organization Extracellular Exosome Cytoskeleton Organization Regulation Of Organelle Organization Profilin Binding Signal Transduction Thioesterase Binding Neuron Fate Determination Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Organelle Organization Vinculin Binding Regulation Of Programmed Cell Death Ameboidal-type Cell Migration Regulation Of Toll-like Receptor 3 Signaling Pathway Cell Surface Receptor Signaling Pathway Immunological Synapse Formation
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