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ARHGEF7 and GIT2
Number of citations of the paper that reports this interaction (PMID
10428811
)
49
Data Source:
HPRD
(in vivo, in vitro)
ARHGEF7
GIT2
Gene Name
Rho guanine nucleotide exchange factor (GEF) 7
G protein-coupled receptor kinase interacting ArfGAP 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ruffle
Cytosol
Focal Adhesion
Cell Cortex
Lamellipodium
Neuron Projection
Neuronal Cell Body
Protein Complex
Nucleoplasm
Focal Adhesion
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Kinase Binding
Protein Binding
ARF GTPase Activator Activity
Zinc Ion Binding
Biological Process
Hematopoietic Progenitor Cell Differentiation
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Axon Guidance
Positive Regulation Of Fibroblast Migration
Lamellipodium Assembly
Positive Regulation Of Rac GTPase Activity
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Focal Adhesion Assembly
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Lamellipodium Morphogenesis
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Regulation Of ARF GTPase Activity
Positive Regulation Of GTPase Activity
Behavioral Response To Pain
Pathways
EGFR downregulation
Signaling by GPCR
Signalling by NGF
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Signaling by Ligand-Responsive EGFR Variants in Cancer
p75 NTR receptor-mediated signalling
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Rho GTPase cycle
Signaling by EGFR
GPCR downstream signaling
Ephrin signaling
NRAGE signals death through JNK
Signaling by Rho GTPases
Signaling by EGFR in Cancer
EPH-Ephrin signaling
G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Bilirubin levels (
19414484
)
Menarche (age at onset) (
21102462
)
Menopause (age at onset) (
19448619
)
Metabolic syndrome (
20694148
)
Metabolite levels (MHPG) (
23319000
)
Protein-Protein Interactions
28 interactors:
ADAM15
ARHGEF6
CALM1
CBLB
CD244
CDC42
ERBB2IP
GIT1
GIT2
LRRK2
MEOX2
NCK1
NCKIPSD
PAK1
PAK2
PAK3
PPM1E
PPM1F
PXN
RAC1
SCRIB
SH2D1A
SHANK1
SHANK2
TGFBR2
TUBB3
WAS
YWHAG
44 interactors:
ACTG1
ACTN1
ADRBK1
ARHGEF7
ATF5
C4BPA
CALCOCO2
CORO1A
E2F2
EDC4
GCH1
GIT1
GUSB
HGD
HNRNPUL1
IKBKG
KCTD5
KRT18
LMNB1
MVP
NFKBIB
NME2
PAK1
PAK3
PCLO
POLR1B
PROX1
PXN
QPRT
RCVRN
RUFY1
RUSC2
SAFB2
SH3GLB2
SMAD3
SPOP
TGFB1I1
TNFAIP3
TNIP1
TRAF1
TSN
UBQLN1
USHBP1
YWHAG
Entrez ID
8874
9815
HPRD ID
05688
09779
Ensembl ID
ENSG00000102606
ENSG00000139436
Uniprot IDs
B7Z6G2
E9PDQ5
Q14155
F8VXI9
Q14161
Q6FI58
PDB IDs
1BY1
1ZSG
2L3G
Enriched GO Terms of Interacting Partners
?
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Kinase Activity
Regulation Of Catalytic Activity
Cell Morphogenesis Involved In Differentiation
Regulation Of Protein Kinase Activity
Regulation Of Signaling
Cell Morphogenesis
Regulation Of Protein Phosphorylation
Regulation Of Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Projection Organization
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stimulus
Cell Communication
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Phosphorylation
Fc Receptor Signaling Pathway
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Programmed Cell Death
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Death
Regulation Of Cell Adhesion
Regulation Of T Cell Activation
Neuron Projection Morphogenesis
Immune Response-regulating Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Organelle Organization
Positive Regulation Of Kinase Activity
Regulation Of Phosphorus Metabolic Process
Cell Development
Movement Of Cell Or Subcellular Component
Regulation Of Cytoskeleton Organization
Positive Regulation Of T Cell Activation
Neuron Development
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Actin Cytoskeleton Organization
Nervous System Development
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Immune System Process
Positive Regulation Of Transferase Activity
Axon Guidance
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Anatomical Structure Morphogenesis
Regulation Of Actin Filament-based Process
Neuron Projection Development
Regulation Of Apoptotic Process
Regulation Of Cell Death
Ephrin Receptor Signaling Pathway
Innate Immune Response
Response To External Stimulus
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stimulus
Apoptotic Process
Regulation Of Signaling
Programmed Cell Death
Regulation Of Signal Transduction
Immune System Process
Immune Response
Regulation Of Immune System Process
Cell Death
Regulation Of Metabolic Process
Death
Positive Regulation Of Immune Response
Defense Response
Signal Transduction
Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
Adherens Junction Organization
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Immune System Process
Focal Adhesion Assembly
Positive Regulation Of Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Phosphorus Metabolic Process
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-cell Junction Organization
Regulation Of Protein Kinase Activity
Positive Regulation Of Catalytic Activity
Signaling
Regulation Of Kinase Activity
Cellular Component Assembly
Cell Communication
Regulation Of Phosphorylation
Adherens Junction Assembly
Regulation Of Protein Phosphorylation
Regulation Of Cellular Component Organization
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Cell Development
Cell-substrate Junction Assembly
Activation Of MAPK Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Response To Stress
Activation Of Innate Immune Response
Cell Surface Receptor Signaling Pathway
Tagcloud
?
ancient
autophosphorylation
coordinates
deregulated
dimerization
exchange
gef
git1
gtpase
guanine
hippo
hpo
interacting
mammals
melanogaster
metazoan
oligomeric
originally
pak
pix
polarity
proteomics
rho
rtgef
salvador
scaffold
sterile
undefined
Tagcloud (Difference)
?
ancient
autophosphorylation
coordinates
deregulated
dimerization
exchange
gef
git1
gtpase
guanine
hippo
hpo
interacting
mammals
melanogaster
metazoan
oligomeric
originally
pak
pix
polarity
proteomics
rho
rtgef
salvador
scaffold
sterile
undefined
Tagcloud (Intersection)
?