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ARHGEF7 and TUBB3
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
ARHGEF7
TUBB3
Gene Name
Rho guanine nucleotide exchange factor (GEF) 7
tubulin, beta 3 class III
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ruffle
Cytosol
Focal Adhesion
Cell Cortex
Lamellipodium
Neuron Projection
Neuronal Cell Body
Protein Complex
Nucleus
Cytoplasm
Microtubule
Axon
Dendrite
Neuronal Cell Body
Extracellular Vesicular Exosome
Cell Periphery
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Kinase Binding
GTPase Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Peptide Binding
Biological Process
Hematopoietic Progenitor Cell Differentiation
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Axon Guidance
Positive Regulation Of Fibroblast Migration
Lamellipodium Assembly
Positive Regulation Of Rac GTPase Activity
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Focal Adhesion Assembly
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Lamellipodium Morphogenesis
Protein Folding
Microtubule-based Process
Mitotic Nuclear Division
Axon Guidance
Cellular Protein Metabolic Process
'de Novo' Posttranslational Protein Folding
Protein Polymerization
Transmembrane Transport
Pathways
EGFR downregulation
Signaling by GPCR
Signalling by NGF
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Signaling by Ligand-Responsive EGFR Variants in Cancer
p75 NTR receptor-mediated signalling
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Rho GTPase cycle
Signaling by EGFR
GPCR downstream signaling
Ephrin signaling
NRAGE signals death through JNK
Signaling by Rho GTPases
Signaling by EGFR in Cancer
EPH-Ephrin signaling
G alpha (12/13) signalling events
Transport of connexons to the plasma membrane
Mitotic Prometaphase
Organelle biogenesis and maintenance
Axon guidance
Hedgehog 'off' state
Separation of Sister Chromatids
Translocation of GLUT4 to the plasma membrane
G2/M Transition
L1CAM interactions
Mitotic Anaphase
Recycling pathway of L1
Recruitment of NuMA to mitotic centrosomes
Formation of tubulin folding intermediates by CCT/TriC
Intraflagellar transport
M Phase
Prefoldin mediated transfer of substrate to CCT/TriC
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Post-chaperonin tubulin folding pathway
Gap junction trafficking and regulation
MHC class II antigen presentation
Recruitment of mitotic centrosome proteins and complexes
Orphan transporters
Protein folding
Gap junction assembly
Gap junction trafficking
Kinesins
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Assembly of the primary cilium
Factors involved in megakaryocyte development and platelet production
Cell Cycle, Mitotic
Resolution of Sister Chromatid Cohesion
Chaperonin-mediated protein folding
Signaling by Hedgehog
Centrosome maturation
Mitotic G2-G2/M phases
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Epothilone D
Epothilone B
Ixabepilone
Diseases
GWAS
Bilirubin levels (
19414484
)
Menarche (age at onset) (
21102462
)
Menopause (age at onset) (
19448619
)
Protein-Protein Interactions
28 interactors:
ADAM15
ARHGEF6
CALM1
CBLB
CD244
CDC42
ERBB2IP
GIT1
GIT2
LRRK2
MEOX2
NCK1
NCKIPSD
PAK1
PAK2
PAK3
PPM1E
PPM1F
PXN
RAC1
SCRIB
SH2D1A
SHANK1
SHANK2
TGFBR2
TUBB3
WAS
YWHAG
27 interactors:
ANXA7
ARHGEF7
CAMSAP3
CDKN1A
DDX39B
EEF1G
GABARAP
GZMK
HEXDC
INSM1
KHDRBS1
LAPTM4A
LIG1
MRPL28
MTCL1
PHIP
PLK1
RCC1
RILPL2
ROBO1
SEL1L3
SMN1
SPTSSA
TERF1
TF
TK1
TPTE
Entrez ID
8874
10381
HPRD ID
05688
04044
Ensembl ID
ENSG00000102606
ENSG00000258947
Uniprot IDs
B7Z6G2
E9PDQ5
Q14155
A8K854
Q13509
Q53G92
PDB IDs
1BY1
1ZSG
2L3G
Enriched GO Terms of Interacting Partners
?
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Kinase Activity
Regulation Of Catalytic Activity
Cell Morphogenesis Involved In Differentiation
Regulation Of Protein Kinase Activity
Regulation Of Signaling
Cell Morphogenesis
Regulation Of Protein Phosphorylation
Regulation Of Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Projection Organization
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stimulus
Cell Communication
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Phosphorylation
Fc Receptor Signaling Pathway
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Programmed Cell Death
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Death
Regulation Of Cell Adhesion
Regulation Of T Cell Activation
Neuron Projection Morphogenesis
Immune Response-regulating Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Organelle Organization
Positive Regulation Of Kinase Activity
Regulation Of Phosphorus Metabolic Process
Cell Development
Movement Of Cell Or Subcellular Component
Regulation Of Cytoskeleton Organization
Positive Regulation Of T Cell Activation
Neuron Development
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Actin Cytoskeleton Organization
Nervous System Development
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Immune System Process
Positive Regulation Of Transferase Activity
Axon Guidance
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Anatomical Structure Morphogenesis
Regulation Of Actin Filament-based Process
Neuron Projection Development
Regulation Of Cell Cycle Process
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle
Mitotic Cell Cycle Phase Transition
G2/M Transition Of Mitotic Cell Cycle
Cell Cycle Phase Transition
Regulation Of Mitotic Nuclear Division
Positive Regulation Of Cell Cycle
Positive Regulation Of Mitotic Nuclear Division
Regulation Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Negative Regulation Of Cell Cycle
Mitotic Cell Cycle
Positive Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Cell Division
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cell Division
Cell Cycle
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Telomere Maintenance Via Telomere Lengthening
Mitotic Spindle Assembly Checkpoint
Cell Cycle Process
Mitotic Cell Cycle Process
Mitotic Cell Cycle Checkpoint
Spindle Assembly Checkpoint
Mitotic Spindle Checkpoint
Response To Toxic Substance
Negative Regulation Of Chromosome Segregation
Cell Division
Cytoskeleton Organization
Microtubule Bundle Formation
Positive Regulation Of Microtubule Motor Activity
Fetal Process Involved In Parturition
Columnar/cuboidal Epithelial Cell Development
Regulation Of DNA Biosynthetic Process
Microtubule-based Process
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Nuclear Division
Spindle Checkpoint
Regulation Of Mitotic Metaphase/anaphase Transition
Epithelial Cell Development
Regulation Of Cell Morphogenesis
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Cell Cycle Checkpoint
Spliceosomal Complex Assembly
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud
?
actb
assessments
bestkeeper
brca1
colon
ercc1
esophageal
gapdh
gastrointestinal
genorm
gusb
normalized
normfinder
optimal
personalized
qrt
ranking
rectal
reference
represented
rplpo
rrm1
separately
stmn1
taqman
tfrc
top2a
tyms
vegfr2
Tagcloud (Difference)
?
actb
assessments
bestkeeper
brca1
colon
ercc1
esophageal
gapdh
gastrointestinal
genorm
gusb
normalized
normfinder
optimal
personalized
qrt
ranking
rectal
reference
represented
rplpo
rrm1
separately
stmn1
taqman
tfrc
top2a
tyms
vegfr2
Tagcloud (Intersection)
?