ARHGEF7 and NOX1

Number of citations of the paper that reports this interaction (PubMedID 16329988)
0

Data Source:
BioGRID (pull down)

		ARHGEF7	NOX1
Description		Rho guanine nucleotide exchange factor 7	NADPH oxidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Centrosome Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Cell Projection Neuron Projection Neuronal Cell Body Anchoring Junction Mitotic Spindle Pole Postsynapse	Cytoplasm Endosome Early Endosome Plasma Membrane Membrane Cell Projection NADPH Oxidase Complex Anchoring Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Gamma-tubulin Binding	Protein Binding NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity Small GTPase Binding Metal Ion Binding NADP Binding Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Superoxide-generating NADPH Oxidase Activity
	Biological Process	Golgi Organization Signal Transduction Rho Protein Signal Transduction Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Microtubule Nucleation Positive Regulation Of Lamellipodium Morphogenesis	MAPK Cascade Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin NADP+ Metabolic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Migration Extracellular Matrix Organization Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Integrin Biosynthetic Process Respiratory Burst Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Hyperoxia Oxygen Metabolic Process Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		EGFR downregulation NRAGE signals death through JNK Ephrin signaling G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle	RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs			Oxygen
Diseases
GWAS		Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824) Weight ( 34074324)
Interacting Genes		37 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN FXR1 FXR2 GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PRRG4 PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 VHL WAS YWHAG	6 interacting genes: ARHGEF7 CYBA FBXW7 NOXA1 NOXO1 TBXA2R
Entrez ID		8874	27035
HPRD ID		05688	02203
Ensembl ID		ENSG00000102606	ENSG00000007952
Uniprot IDs		A0A2R8YG42 A0A8V8TQ72 B1ALK7 B7Z344 B7Z6G2 E9PDQ5 Q14155	A6NGA6 Q1ZYL4 Q9Y5S8
PDB IDs		1BY1 1ZSG 2L3G 5SXP
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Stress Fiber Assembly Postsynapse Regulation Of Cell Communication Regulation Of Actin Cytoskeleton Organization Regulation Of Signal Transduction Regulation Of Actin Filament-based Process Cell-cell Junction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cytoskeleton Organization Signal Transduction Glutamatergic Synapse Positive Regulation Of Stress Fiber Assembly Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cytoskeleton Organization Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Plasma Membrane Modulation Of Chemical Synaptic Transmission Enzyme-linked Receptor Protein Signaling Pathway Cell Projection Small GTPase Binding SH3 Domain Binding Lamellipodium Regulation Of Synaptic Plasticity Cytosol Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Dendrite Neuron Projection Regulation Of Organelle Organization Cytoplasm Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Organelle Organization Protein Localization To Cell Junction Postsynaptic Density Positive Regulation Of T Cell Tolerance Induction Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Regulation Of Locomotion	NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Respiratory Burst Positive Regulation Of Blood Pressure Smooth Muscle Hypertrophy Negative Regulation Of Glomerular Filtration By Angiotensin Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Negative Regulation Of Microtubule Nucleation SH3 Domain Binding Regulation Of Renal Output By Angiotensin Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Cellular Response To L-glutamine Regulation Of Blood Pressure Cellular Response To Radiation Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mucus Secretion Ubiquitin Recycling Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development Regulation Of Blood Volume By Renin-angiotensin Smooth Muscle Adaptation Response To Ketone Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Lamellipodium Morphogenesis Regulation Of Mucus Secretion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Muscle System Process Ubiquitin-protein Transferase Activator Activity Regulation Of Osteoclast Development Hydrogen Peroxide Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Superoxide-generating NAD(P)H Oxidase Activity Regulation Of Body Fluid Levels Cellular Response To Phorbol 13-acetate 12-myristate Response To Alcohol Regulation Of Lamellipodium Morphogenesis Regulation Of SREBP Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Defense Response To Bacterium
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