ARHGEF7 and PAK3

Number of citations of the paper that reports this interaction (PMID 9726964)
78

Data Source:
HPRD (in vivo)

		ARHGEF7	PAK3
Gene Name		Rho guanine nucleotide exchange factor (GEF) 7	p21 protein (Cdc42/Rac)-activated kinase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytosol Focal Adhesion Cell Cortex Lamellipodium Neuron Projection Neuronal Cell Body Protein Complex	Cytoplasm Endosome Cytosol Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Rho GTPase Binding SH3 Domain Binding Metal Ion Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Positive Regulation Of Rac GTPase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Lamellipodium Morphogenesis	MAPK Cascade Activation Of MAPK Activity Mitotic Cell Cycle Protein Phosphorylation Axonogenesis Axon Guidance Dendrite Development Signal Transduction By Phosphorylation Regulation Of Actin Filament Polymerization T Cell Costimulation Positive Regulation Of Neuron Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synapse Organization T Cell Receptor Signaling Pathway Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of DNA Biosynthetic Process
Pathways		EGFR downregulation Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Rho GTPase cycle Signaling by EGFR GPCR downstream signaling Ephrin signaling NRAGE signals death through JNK Signaling by Rho GTPases Signaling by EGFR in Cancer EPH-Ephrin signaling G alpha (12/13) signalling events	Generation of second messenger molecules Costimulation by the CD28 family Axon guidance Semaphorin interactions CD28 co-stimulation FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway CD28 dependent Vav1 pathway Ephrin signaling TCR signaling Activation of Rac Signaling by VEGF VEGFR2 mediated vascular permeability EPH-Ephrin signaling Fc epsilon receptor (FCERI) signaling Sema3A PAK dependent Axon repulsion Signaling by Robo receptor Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS		Bilirubin levels ( 19414484) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619)
Protein-Protein Interactions		28 interactors: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 ERBB2IP GIT1 GIT2 LRRK2 MEOX2 NCK1 NCKIPSD PAK1 PAK2 PAK3 PPM1E PPM1F PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG	12 interactors: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 SNCA SYN1
Entrez ID		8874	5063
HPRD ID		05688	02142
Ensembl ID		ENSG00000102606	ENSG00000077264
Uniprot IDs		B7Z6G2 E9PDQ5 Q14155	B2RCU6 O75914
PDB IDs		1BY1 1ZSG 2L3G
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Kinase Activity Regulation Of Signaling Cell Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Programmed Cell Death Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Death Regulation Of Cell Adhesion Regulation Of T Cell Activation Neuron Projection Morphogenesis Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Positive Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Cell Development Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Positive Regulation Of T Cell Activation Neuron Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Actin Cytoskeleton Organization Nervous System Development Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Positive Regulation Of Transferase Activity Axon Guidance Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Anatomical Structure Morphogenesis Regulation Of Actin Filament-based Process Neuron Projection Development	Lamellipodium Assembly Lamellipodium Organization Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Projection Assembly Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Cell Morphogenesis Involved In Differentiation Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signal Transduction Neuron Projection Development Movement Of Cell Or Subcellular Component Axonogenesis Neuron Development Ephrin Receptor Signaling Pathway Axon Development Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Chemotaxis Cell Morphogenesis Positive Regulation Of Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Morphogenesis Regulation Of Ras Protein Signal Transduction Neuron Differentiation Regulation Of Protein Complex Assembly Cell Development Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Component Assembly Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Signaling Cell Projection Morphogenesis Cell Communication Cell Part Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Kinase Activity Cell-cell Junction Organization Regulation Of Cell Death
Tagcloud ?			acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pathoetiology plcb1 pxn skew sos1 unacclimatized vasoconstriction vcam1
Tagcloud (Difference) ?			acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pathoetiology plcb1 pxn skew sos1 unacclimatized vasoconstriction vcam1
Tagcloud (Intersection) ?