CDK5R1 and CAPN1

Number of citations of the paper that reports this interaction (PubMedID 10830966)
0

Data Source:
HPRD (in vivo, in vitro)

		CDK5R1	CAPN1
Description		cyclin dependent kinase 5 regulatory subunit 1	calpain 1
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Axon Dendrite Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Contractile Muscle Fiber Perinuclear Region Of Cytoplasm	Cornified Envelope Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Calpain Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Protease Binding Actin Binding Protein Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Protein Kinase Binding Protein Kinase Activator Activity Ionotropic Glutamate Receptor Binding Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Beta-tubulin Binding Actin Filament Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Neuron Migration Neuron Cell-cell Adhesion G Protein-coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Cerebral Cortex Radially Oriented Cell Migration Layer Formation In Cerebral Cortex Neuron Differentiation Positive Regulation Of Microtubule Polymerization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis G1 To G0 Transition Involved In Cell Differentiation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis NMDA Selective Glutamate Receptor Signaling Pathway
Pathways		CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Indirubin-3'-monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE	4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS			Urate levels ( 31578528)
Interacting Genes		35 interacting genes: ACTN1 AMPH APP BCL2L13 BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 FEM1B FEM1C HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NLA ODF1 PAK1 SEPTIN5 SET SIAH1 STXBP1 TSC22D4 TTBK1	55 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KCTD7 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		8851	823
HPRD ID		04586	00253
Ensembl ID		ENSG00000176749	ENSG00000014216
Uniprot IDs		Q15078 Q8N619	B2RDI5 B4DWH5 P07384
PDB IDs		1H4L 1UNG 1UNH 1UNL 3O0G 6LDP 7CNG 7VDP 7VDQ 7VDR 7VDS	1ZCM 2ARY 7W7O 7X79 8GX3
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Cytoplasm Developmental Process Cytosol Regulation Of Programmed Cell Death Positive Regulation Of Protein Polymerization Receptor Metabolic Process Acetylcholine Receptor Activator Activity Protein Kinase Binding Neurofibrillary Tangle Assembly Neuron Projection Development Protein Serine Kinase Activity Receptor Catabolic Process Developmental Growth Involved In Morphogenesis Apoptotic Process Regulation Of Neuron Apoptotic Process Regulation Of Developmental Process Perinuclear Region Of Cytoplasm Regulation Of Protein Localization Programmed Cell Death Cell Death Protein Serine/threonine Kinase Activity Establishment Of Organelle Localization Calpain Complex Cyclin-dependent Protein Serine/threonine Kinase Activity Amyloid Fibril Formation Cellular Developmental Process Regulation Of Neurotransmitter Secretion Main Axon Vesicle-mediated Transport In Synapse Positive Regulation Of Microtubule Polymerization Dendrite Organelle Localization Cell Differentiation Establishment Of Localization In Cell Regulation Of Cell Differentiation Synaptic Vesicle Transport NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Cell Projection Organization Establishment Of Vesicle Localization Synaptic Vesicle Endocytosis Protein Kinase Activity Neuron Apoptotic Process Neuronal Cell Body Presynaptic Endocytosis Tau Protein Binding Oligodendrocyte Differentiation Developmental Cell Growth	Organelle Organization Regulation Of Programmed Cell Death Response To Alcohol Regulation Of Organelle Organization Regulation Of Apoptotic Process Identical Protein Binding Positive Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Protease Binding Cytoplasm Regulation Of Signal Transduction Regulation Of Cellular Component Organization Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Amino Acid Stimulus Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Programmed Cell Death Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Hepatocyte Apoptotic Process Cytosol Regulation Of Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Cell Junction Maintenance Regulation Of Renin Secretion Into Blood Stream Regulation Of Autophagy Sarcomere Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Mitochondrial Membrane Permeability G-protein Beta-subunit Binding Regulation Of Protein Localization Response To Amino Acid Release Of Cytochrome C From Mitochondria Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Fluoride Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Apoptotic Process Cellular Component Maintenance Regulation Of Membrane Permeability Cysteine-type Peptidase Activity Positive Regulation Of Cellular Component Organization Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Protein Localization
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