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CDK5R1 and STXBP1
Number of citations of the paper that reports this interaction (PubMedID
9933594
)
0
Data Source:
HPRD
(in vitro)
CDK5R1
STXBP1
Description
cyclin dependent kinase 5 regulatory subunit 1
syntaxin binding protein 1
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Cell Projection
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Perikaryon
Contractile Muscle Fiber
Perinuclear Region Of Cytoplasm
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Membrane
Secretory Granule
Axon
Platelet Alpha Granule
Protein-containing Complex
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Parallel Fiber To Purkinje Cell Synapse
Presynapse
Postsynapse
Presynaptic Active Zone Cytoplasmic Component
Extrinsic Component Of Presynaptic Membrane
Glutamatergic Synapse
Presynaptic Cytosol
Molecular Function
Protease Binding
Actin Binding
Protein Kinase Activity
Calcium Ion Binding
Protein Binding
Kinase Activity
Protein Kinase Binding
Protein Kinase Activator Activity
Ionotropic Glutamate Receptor Binding
Alpha-tubulin Binding
Protein Serine/threonine Kinase Activator Activity
Cadherin Binding
Beta-tubulin Binding
Actin Filament Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
SNARE Binding
RNA Binding
Protein Binding
Syntaxin-1 Binding
Protein Kinase Binding
Protein Domain Specific Binding
Syntaxin Binding
Identical Protein Binding
Phospholipase Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Microtubule Cytoskeleton Organization
Neuron Migration
Neuron Cell-cell Adhesion
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Axon Guidance
Axonal Fasciculation
Brain Development
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cerebellum Development
Superior Olivary Nucleus Maturation
Hippocampus Development
Cerebral Cortex Radially Oriented Cell Migration
Layer Formation In Cerebral Cortex
Neuron Differentiation
Positive Regulation Of Microtubule Polymerization
Neuron Projection Development
Regulation Of Actin Cytoskeleton Organization
Ionotropic Glutamate Receptor Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of MHC Class II Biosynthetic Process
Regulation Of Neuron Differentiation
Negative Regulation Of DNA-templated Transcription
Ephrin Receptor Signaling Pathway
Rhythmic Process
Regulation Of Dendritic Spine Morphogenesis
G1 To G0 Transition Involved In Cell Differentiation
Regulation Of Microtubule Cytoskeleton Organization
Positive Regulation Of Protein Targeting To Membrane
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Platelet Degranulation
Developmental Process Involved In Reproduction
Intracellular Protein Transport
Exocytosis
Vesicle Docking Involved In Exocytosis
Neurotransmitter Secretion
Neuromuscular Synaptic Transmission
Axon Target Recognition
Regulation Of Synaptic Vesicle Priming
Protein Transport
Synaptic Vesicle Priming
Synaptic Vesicle Maturation
Vesicle-mediated Transport
Negative Regulation Of Protein-containing Complex Assembly
Regulation Of Vesicle Fusion
Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Negative Regulation Of Synaptic Transmission, GABAergic
Response To Estradiol
SNARE Complex Assembly
Regulation Of SNARE Complex Assembly
Positive Regulation Of Mast Cell Degranulation
Negative Regulation Of Neuron Apoptotic Process
Regulated Exocytosis
Positive Regulation Of Exocytosis
Positive Regulation Of Calcium Ion-dependent Exocytosis
Protein Stabilization
Neuron Apoptotic Process
Establishment Of Localization In Cell
Long-term Synaptic Depression
Platelet Aggregation
Cellular Response To Type II Interferon
Protein Localization To Plasma Membrane
Presynaptic Dense Core Vesicle Exocytosis
Positive Regulation Of Vesicle Docking
Positive Regulation Of Glutamate Secretion, Neurotransmission
Regulation Of Regulated Secretory Pathway
Regulation Of Acrosomal Vesicle Exocytosis
Pathways
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
NPAS4 regulates expression of target genes
Regulation of insulin secretion
Neurexins and neuroligins
Drugs
Indirubin-3'-monoxime
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS
Body size at age 10 (
32376654
)
Whole brain grey matter density (
31530798
)
Interacting Genes
35 interacting genes:
ACTN1
AMPH
APP
BCL2L13
BLOC1S6
CAMK2A
CAPN1
CAPN2
CDK16
CDK5
CDK5RAP1
CDK5RAP2
CDK5RAP3
CDK9
CHN1
CTNNB1
FEM1B
FEM1C
HSP90AA1
KRT40
KRTAP10-3
LMTK2
MAPT
MTUS2
NEDD4
NES
NOTCH2NLA
ODF1
PAK1
SEPTIN5
SET
SIAH1
STXBP1
TSC22D4
TTBK1
35 interacting genes:
APBA1
APBA2
APP
BRME1
CDK5
CDK5R1
CENPP
DOC2A
DOC2B
HGS
MAPK1
MAPT
MEOX2
MTDH
MTNR1A
NEFH
NEFM
PLD1
PLD2
PRKCA
PRKCB
PRKCG
RIPPLY3
SPICE1
SPTBN1
SQSTM1
STX1A
STX1B
STX2
STX3
STX5
SYTL4
TRIM38
TTC3
USO1
Entrez ID
8851
6812
HPRD ID
04586
04235
Ensembl ID
ENSG00000176749
ENSG00000136854
Uniprot IDs
Q15078
Q8N619
A0A0D9SG72
A0A1B0GTP9
A0A1B0GVQ5
A0A1B0GWF2
P61764
PDB IDs
1H4L
1UNG
1UNH
1UNL
3O0G
6LDP
7CNG
7VDP
7VDQ
7VDR
7VDS
6L03
Enriched GO Terms of Interacting Partners
?
Regulation Of Apoptotic Process
Cytoplasm
Developmental Process
Cytosol
Regulation Of Programmed Cell Death
Positive Regulation Of Protein Polymerization
Receptor Metabolic Process
Acetylcholine Receptor Activator Activity
Protein Kinase Binding
Neurofibrillary Tangle Assembly
Neuron Projection Development
Protein Serine Kinase Activity
Receptor Catabolic Process
Developmental Growth Involved In Morphogenesis
Apoptotic Process
Regulation Of Neuron Apoptotic Process
Regulation Of Developmental Process
Perinuclear Region Of Cytoplasm
Regulation Of Protein Localization
Programmed Cell Death
Cell Death
Protein Serine/threonine Kinase Activity
Establishment Of Organelle Localization
Calpain Complex
Cyclin-dependent Protein Serine/threonine Kinase Activity
Amyloid Fibril Formation
Cellular Developmental Process
Regulation Of Neurotransmitter Secretion
Main Axon
Vesicle-mediated Transport In Synapse
Positive Regulation Of Microtubule Polymerization
Dendrite
Organelle Localization
Cell Differentiation
Establishment Of Localization In Cell
Regulation Of Cell Differentiation
Synaptic Vesicle Transport
NMDA Selective Glutamate Receptor Signaling Pathway
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Synaptic Plasticity
Cell Projection Organization
Establishment Of Vesicle Localization
Synaptic Vesicle Endocytosis
Protein Kinase Activity
Neuron Apoptotic Process
Neuronal Cell Body
Presynaptic Endocytosis
Tau Protein Binding
Oligodendrocyte Differentiation
Developmental Cell Growth
Regulation Of Vesicle-mediated Transport
Modulation Of Chemical Synaptic Transmission
Regulation Of Exocytosis
Vesicle-mediated Transport
Positive Regulation Of Exocytosis
SNARE Complex
Vesicle Docking
Intracellular Protein Transport
Exocytosis
Synaptic Vesicle Exocytosis
Positive Regulation Of Secretion By Cell
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Transport
Positive Regulation Of Secretion
SNAP Receptor Activity
Organelle Localization By Membrane Tethering
Positive Regulation Of Synaptic Transmission
Regulation Of Protein Localization
Establishment Of Localization In Cell
Organelle Localization
Membrane Docking
Regulation Of Transport
Vesicle-mediated Transport In Synapse
Positive Regulation Of Calcium Ion-dependent Exocytosis
Membrane Organization
Vesicle Fusion
Organelle Membrane Fusion
Neurofibrillary Tangle
Secretion By Cell
Regulation Of Establishment Of Protein Localization
Establishment Of Protein Localization
Spontaneous Neurotransmitter Secretion
Regulation Of Secretion By Cell
Regulation Of Synaptic Plasticity
Chemical Synaptic Transmission
Positive Regulation Of Protein Localization
Regulation Of Regulated Secretory Pathway
Vesicle Organization
SNARE Binding
Positive Regulation Of Establishment Of Protein Localization
Organelle Fusion
Presynaptic Active Zone Membrane
Trans-synaptic Signaling
Intracellular Transport
Neuron Projection
Regulation Of Secretion
Presynapse
Synaptic Signaling
Regulation Of Signaling
Regulation Of Cell Communication
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Tagcloud (Intersection)
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