CDK5R1 and CDK5RAP1

Number of citations of the paper that reports this interaction (PMID 10721722)
22

Data Source:
HPRD (in vitro, in vivo)

		CDK5R1	CDK5RAP1
Gene Name		cyclin-dependent kinase 5, regulatory subunit 1 (p35)	CDK5 regulatory subunit associated protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex Axon Dendrite Growth Cone Neuromuscular Junction Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Contractile Fiber Perinuclear Region Of Cytoplasm	Cellular_component Cytoplasm
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Cyclin-dependent Protein Kinase 5 Activator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ephrin Receptor Binding	Transferase Activity Protein Kinase Binding Protein Complex Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Migration Neuron Cell-cell Adhesion G-protein Coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Cell Proliferation Embryo Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Neuron Differentiation Negative Regulation Of Axon Extension Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Serine Phosphorylation Of STAT3 Protein Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Targeting To Membrane	TRNA Modification Brain Development Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Pathways		Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ACTN1 AMPH APP BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NL ODF1 PAK1 SET SIAH1 STXBP1 TSC22D4 TTBK1	4 interactors: CDK5 CDK5R1 EXOSC3 EXOSC5
Entrez ID		8851	51654
HPRD ID		04586	12189
Ensembl ID		ENSG00000176749	ENSG00000101391
Uniprot IDs		Q15078 Q8N619	Q53H36 Q96SZ6
PDB IDs		1H4L 1UNG 1UNH 1UNL 3O0G
Enriched GO Terms of Interacting Partners?		Generation Of Neurons Nervous System Development Neurogenesis Establishment Of Localization In Cell Neuron Projection Development Cellular Localization Neuron Differentiation Cell Differentiation Cell Projection Organization Neuron Development Multicellular Organismal Development Vesicle-mediated Transport Regulation Of Organelle Organization Regulation Of Neurogenesis Establishment Of Organelle Localization Regulation Of Cellular Component Organization Developmental Process Cell Morphogenesis Involved In Differentiation Exocytosis Axonogenesis Synaptic Vesicle Transport Regulation Of Neuron Differentiation Cell Morphogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Morphogenesis Cell Development Regulation Of Cell Development System Development Cell Part Morphogenesis Organelle Localization Neuron Projection Morphogenesis Receptor Catabolic Process Anatomical Structure Development Synapse Organization Regulation Of Cytoskeleton Organization Secretion By Cell Brain Development Receptor Metabolic Process Response To Abiotic Stimulus Head Development Establishment Of Vesicle Localization Negative Regulation Of Neuron Death Vesicle Localization Axon Guidance Regulation Of Cell Differentiation Secretion Anatomical Structure Morphogenesis Regulation Of Cell Cycle Locomotion	Serine Phosphorylation Of STAT3 Protein Serine Phosphorylation Of STAT Protein DNA Deamination Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Negative Regulation Of Axon Extension Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Protein Targeting To Membrane Regulation Of Dendritic Spine Morphogenesis Layer Formation In Cerebral Cortex Cerebral Cortex Radial Glia Guided Migration Peptidyl-threonine Phosphorylation Regulation Of Dendritic Spine Development Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Neuron Apoptotic Process Cerebral Cortex Radially Oriented Cell Migration Negative Regulation Of Axonogenesis Glial Cell Migration Regulation Of Axon Extension Regulation Of Dendrite Morphogenesis Hippocampus Development Positive Regulation Of Neuron Death DNA Modification Negative Regulation Of Developmental Growth Cerebral Cortex Cell Migration Regulation Of JAK-STAT Cascade Limbic System Development Regulation Of Cell Cycle Arrest Negative Regulation Of Cell Morphogenesis Involved In Differentiation Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Dendrite Development RNA Phosphodiester Bond Hydrolysis Cerebellum Development Peptidyl-serine Phosphorylation Negative Regulation Of Neuron Projection Development Metencephalon Development RRNA Processing Regulation Of Cell Size RRNA Metabolic Process Negative Regulation Of Cell Projection Organization Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Cell Growth Regulation Of Axonogenesis MRNA Catabolic Process Cerebral Cortex Development Positive Regulation Of Intracellular Protein Transport Neuron Migration Hindbrain Development Superior Olivary Nucleus Maturation
Tagcloud ?		10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3	acetyl arrested caspase converts cysteine deficiency deficient g2 i6a incubated interfering iso isopentenyladenosine jnk jun mcf methylthio ms2i6a n6 nac pentenyladenosine phospho pretreatment ros sirna sp600125 synthetically upregulated world
Tagcloud (Difference) ?		10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3	acetyl arrested caspase converts cysteine deficiency deficient g2 i6a incubated interfering iso isopentenyladenosine jnk jun mcf methylthio ms2i6a n6 nac pentenyladenosine phospho pretreatment ros sirna sp600125 synthetically upregulated world
Tagcloud (Intersection) ?